TM4SF5
| Transmembrane 4 L six family member 5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | TM4SF5 | ||||||||||
| External IDs | OMIM: 604657 MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5 Gene | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 9032 | 75604 | |||||||||
| Ensembl | ENSG00000142484 | ENSMUSG00000018919 | |||||||||
| UniProt | O14894 | Q91XF2 | |||||||||
| RefSeq (mRNA) | NM_003963 | NM_029360 | |||||||||
| RefSeq (protein) | NP_003954 | NP_083636 | |||||||||
| Location (UCSC) |
Chr 17: 4.77 – 4.78 Mb |
Chr 11: 70.51 – 70.51 Mb | |||||||||
| PubMed search | |||||||||||
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1][2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[2]
References
- ↑ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.
- 1 2 "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".
Further reading
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Lee SY, Kim YT, Lee MS, et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment". Exp. Cell Res. 312 (16): 2983–99. doi:10.1016/j.yexcr.2006.06.001. PMID 16828471.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". Am. J. Gastroenterol. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983.
- Wright MD, Ni J, Rudy GB (2000). "The L6 membrane proteins--a new four-transmembrane superfamily". Protein Sci. 9 (8): 1594–600. doi:10.1110/ps.9.8.1594. PMC 2144728. PMID 10975581.
- Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. PMID 8895530.