TMEFF2

Transmembrane protein with EGF-like and two follistatin-like domains 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FMW​
Identifiers
Symbols	TMEFF2 ; CT120.2; HPP1; TENB2; TPEF; TR; TR-2
External IDs	OMIM: 605734 MGI: 1861735 HomoloGene: 9417 GeneCards: TMEFF2 Gene
Gene ontology Molecular function • molecular_function Cellular component • extracellular region • integral component of membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23671	56363
Ensembl	ENSG00000144339	ENSMUSG00000026109
UniProt	Q9UIK5	Q9QYM9
RefSeq (mRNA)	NM_001305134	NM_019790
RefSeq (protein)	NP_001292063	NP_062764
Location (UCSC)	Chr 2: 191.95 – 192.2 Mb	Chr 1: 50.9 – 51.19 Mb
PubMed search

Tomoregulin-2 is a protein that in humans is encoded by the TMEFF2 gene.^[1][2]

References

1. Horie M, Mitsumoto Y, Kyushiki H, Kanemoto N, Watanabe A, Taniguchi Y, Nishino N, Okamoto T, Kondo M, Mori T, Noguchi K, Nakamura Y, Takahashi E, Tanigami A (Aug 2000). "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons". Genomics 67 (2): 146–52. doi:10.1006/geno.2000.6228. PMID 10903839.
2. "Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Uchida T, Wada K, Akamatsu T, et al. (2000). "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells". Biochem. Biophys. Res. Commun. 266 (2): 593–602. doi:10.1006/bbrc.1999.1873. PMID 10600548.
• Liang G, Robertson KD, Talmadge C, et al. (2000). "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells". Cancer Res. 60 (17): 4907–12. PMID 10987305.
• Young J, Biden KG, Simms LA, et al. (2001). "HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 265–70. doi:10.1073/pnas.011415298. PMC 14579. PMID 11120884.
• Glynne-Jones E, Harper ME, Seery LT, et al. (2001). "TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence". Int. J. Cancer 94 (2): 178–84. doi:10.1002/ijc.1450. PMID 11668495.
• Shibata DM, Sato F, Mori Y, et al. (2002). "Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas". Cancer Res. 62 (20): 5637–40. PMID 12384516.
• Sato F, Shibata D, Harpaz N, et al. (2003). "Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma". Cancer Res. 62 (23): 6820–2. PMID 12460892.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gery S, Koeffler HP (2003). "Repression of the TMEFF2 promoter by c-Myc". J. Mol. Biol. 328 (5): 977–83. doi:10.1016/S0022-2836(03)00404-2. PMID 12729735.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sabbioni S, Miotto E, Veronese A, et al. (2004). "Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood". Mol. Diagn. 7 (3–4): 201–7. doi:10.2165/00066982-200307030-00010. PMID 15068392.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Schulmann K, Sterian A, Berki A, et al. (2005). "Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk". Oncogene 24 (25): 4138–48. doi:10.1038/sj.onc.1208598. PMID 15824739.
• Suzuki M, Shigematsu H, Shames DS, et al. (2005). "DNA methylation-associated inactivation of TGFβ-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers". Br. J. Cancer 93 (9): 1029–37. doi:10.1038/sj.bjc.6602837. PMC 2361683. PMID 16234815.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.