TMPRSS6

Transmembrane protease, serine 6
Identifiers
Symbols	TMPRSS6 ; IRIDA
External IDs	OMIM: 609862 MGI: 1919003 HomoloGene: 12408 ChEMBL: 1795139 GeneCards: TMPRSS6 Gene
Gene ontology Molecular function • serine-type endopeptidase activity • protein binding Cellular component • extracellular space • intracellular • plasma membrane • integral component of membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • angiogenesis • proteolysis • cellular iron ion homeostasis • extracellular matrix organization • negative regulation of BMP signaling pathway • membrane protein proteolysis • intracellular signal transduction • fibrinolysis • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • iron ion homeostasis • self proteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	164656	71753
Ensembl	ENSG00000187045	ENSMUSG00000016942
UniProt	Q8IU80	Q9DBI0
RefSeq (mRNA)	NM_001289000	NM_027902
RefSeq (protein)	NP_001275929	NP_082178
Location (UCSC)	Chr 22: 37.07 – 37.11 Mb	Chr 15: 78.44 – 78.47 Mb
PubMed search

Transmembrane protease, serine 6 is an enzyme that in humans is encoded by the TMPRSS6 gene.^[1]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.^[1]

References

1. "Entrez Gene: TMPRSS6 transmembrane protease, serine 6".

Further reading

• Netzel-Arnett S, Hooper JD, Szabo R, et al. (2004). "Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer". Cancer Metastasis Rev. 22 (2–3): 237–58. doi:10.1023/A:1023003616848. PMID 12784999.
• Ramsay AJ, Reid JC, Velasco G, et al. (2007). "The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles". Front. Biosci. 13 (13): 569–79. doi:10.2741/2702. PMID 17981570.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Velasco G, Cal S, Quesada V, et al. (2002). "Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins". J. Biol. Chem. 277 (40): 37637–46. doi:10.1074/jbc.M203007200. PMID 12149247.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hartikainen JM, Tuhkanen H, Kataja V, et al. (2006). "Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population". Clin. Cancer Res. 12 (5): 1454–62. doi:10.1158/1078-0432.CCR-05-1417. PMID 16533768.
• Parr C, Sanders AJ, Davies G, et al. (2007). "Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients". Clin. Cancer Res. 13 (12): 3568–76. doi:10.1158/1078-0432.CCR-06-2357. PMID 17575220.