TMUB2
| Transmembrane and ubiquitin-like domain containing 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TMUB2 ; FP2653 | ||||||||||||
| External IDs | MGI: 1919303 HomoloGene: 18581 GeneCards: TMUB2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79089 | 72053 | |||||||||||
| Ensembl | ENSG00000168591 | ENSMUSG00000034757 | |||||||||||
| UniProt | Q71RG4 | Q3V209 | |||||||||||
| RefSeq (mRNA) | NM_001076674 | NM_001302505 | |||||||||||
| RefSeq (protein) | NP_001070142 | NP_001289434 | |||||||||||
| Location (UCSC) |
Chr 17: 44.19 – 44.19 Mb |
Chr 11: 102.28 – 102.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[1][2][3]
Gene
TMUB2 maps on the human chromosome 17, at locus 17q21.31.[3] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[4] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[5]
Expression
TMUB2 is likely ubiquitously expressed throughout the human body.[6] It has a high expression level that is 2.9 times higher than other human genes.[7][8]
Protein
The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[9] These will likely vary in orthologs.
Homology
Paralogs
TMUB1 is the only paralog of TMUB2.[10][11] These proteins share a 38% identity and 51% similarity.[12]
Orthologs
The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[12]
| Species | Common Name | Accession Number | Sequence Length (aa) | Sequence Identity | Sequence Similarity |
|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | XP_003953053.1 | 301 | 100% | 100% |
| Felis Catus | Cat | XP_003997025.1 | 322 | 95% | 95% |
| Mus Musculus | Mouse | AAH29841.2 | 319 | 85% | 88% |
| Alligator Mississippiensus | Alligator | XP_006271613.1 | 306 | 61% | 71% |
| Haliaeetus leucocephalus | Bald Eagle | XP_010559728 | 301 | 59% | 70% |
| Danio rerio | Zebrafish | NP_001005573.1 | 291 | 47% | 60% |
| Acromyrmex echinatior | Ant | XP_011049429.1 | 354 | 23% | 42% |
| Nannochloropsis Gaditana* | Algae | EWM26843.1 | 476 | 41% | 54% |
| Coccidioides immitis RS* | Pathogenic Fungus | XP_001242306.1 | 418 | 38% | 50% |
*Limited Query Coverage
Protein Interactions
In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[13][14][15][16] Other proposed interactions include BCL2L13 (BCL2-like 13),[17] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[17] and UBQLN1 (Ubiquilin-1).[17][18][19]
References
- ↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
- ↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- 1 2 "Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2".
- ↑ UCSC Genome Browser: BLAT Search
- ↑ NCBI Gene: TMUB2
- ↑ EST Profile Viewer: Human
- ↑ Aceview: TMUB2
- ↑ NCBI GEO Profiles
- ↑ SDSC Biology Workbench 2.0
- ↑ GeneCards: TMUB2
- ↑ NCBI Gene: TMUB1
- 1 2 NCBI BLAST: Basic Local Alignment Search Tool
- ↑ Danielsen Jannie M R, Sylvestersen Kathrine B, Bekker-Jensen Simon, Szklarczyk Damian, Poulsen Jon W, Horn Heiko, Jensen Lars J, Mailand Niels, Nielsen Michael L (2011). "Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level". Molecular & Cellular Proteomics M110 (3): 003590. doi:10.1074/mcp.M110.003590. PMID 21139048.
- ↑ Wagner S. A., Beli P., Weinert B. T., Nielsen M. L., Cox J., Mann M., Choudhary C. (2011). "A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles". Molecular & Cellular Proteomics 10: M111.013284. doi:10.1074/mcp.M111.013284. PMC 3205876. PMID 21890473.
- ↑ Kim Woong, Bennett Eric J., Huttlin Edward L., Guo Ailan, Li Jing, Possemato Anthony, Sowa Mathew E.; et al. (2011). "Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome". Molecular Cell 44 (2): 325–40. doi:10.1016/j.molcel.2011.08.025. PMC 3200427. PMID 21906983.
- ↑ Povlsen Lou K., Beli Petra, Wagner Sebastian A., Poulsen Sara L., Sylvestersen Kathrine B., Poulsen Jon W., Nielsen Michael L., Bekker-Jensen Simon, Mailand Niels, Choudhary Chunaram (2012). "Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass". Nature Cell Biology 14: 1089–1098. doi:10.1038/ncb2579.
- 1 2 3 Rolland T, Taşan M, Charloteaux B; et al. (Nov 2014). "A proteome-scale map of the human interactome network". Cell 159 (5): 1212–26. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
- ↑ STRING: Functional Protein Association Networks
- ↑ BioGRID Database
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–15729. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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