TNFAIP1

Tumor necrosis factor, alpha-induced protein 1 (endothelial)
Identifiers
Symbols	TNFAIP1 ; B12; B61; BTBD34; EDP1; hBACURD2
External IDs	OMIM: 191161 MGI: 104961 HomoloGene: 22519 GeneCards: TNFAIP1 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • GTP-Rho binding • protein domain specific binding Cellular component • nucleolus • cytoplasm • endosome • Cul3-RING ubiquitin ligase complex Biological process • DNA replication • apoptotic process • immune response • embryo development • cell migration • protein ubiquitination • negative regulation of Rho protein signal transduction • stress fiber assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of DNA replication • protein homooligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7126	21927
Ensembl	ENSG00000109079	ENSMUSG00000017615
UniProt	Q13829	O70479
RefSeq (mRNA)	NM_021137	NM_001159392
RefSeq (protein)	NP_066960	NP_001152864
Location (UCSC)	Chr 17: 28.34 – 28.35 Mb	Chr 11: 78.52 – 78.54 Mb
PubMed search

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.^[1][2][3]

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.^[3]

References

1. Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem 265 (5): 2973–8. PMID 2406243.
2. Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol 10 (11): 5830–8. PMC 361366. PMID 2233719.
3. "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

Further reading

• Wolf FW, Marks RM, Sarma V, et al. (1992). "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene.". J. Biol. Chem. 267 (2): 1317–26. PMID 1370465.
• Pandey A, Shao H, Marks RM, et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis.". Science 268 (5210): 567–9. doi:10.1126/science.7536959. PMID 7536959.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Link CD, Taft A, Kapulkin V, et al. (2003). "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model.". Neurobiol. Aging 24 (3): 397–413. doi:10.1016/S0197-4580(02)00224-5. PMID 12600716.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.