TNIK

TRAF2 and NCK interacting kinase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2X7F​
Identifiers
Symbols	TNIK ; AD 2
External IDs	OMIM: 610005 HomoloGene: 77943 ChEMBL: 4527 GeneCards: TNIK Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • MAP kinase kinase kinase kinase activity Cellular component • nucleus • nucleoplasm • cytoplasm • cytoskeleton • apical plasma membrane • recycling endosome • extracellular exosome Biological process • MAPK cascade • positive regulation of protein phosphorylation • positive regulation of defense response to virus by host • protein phosphorylation • cytoskeleton organization • activation of JNKK activity • regulation of mitotic cell cycle • Wnt signaling pathway • microvillus assembly • stress-activated protein kinase signaling cascade • actin cytoskeleton reorganization • intracellular signal transduction • regulation of apoptotic process • protein autophosphorylation • neuron projection morphogenesis • regulation of dendrite morphogenesis • protein localization to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23043	665113
Ensembl	ENSG00000154310	ENSMUSG00000027692
UniProt	Q9UKE5	P83510
RefSeq (mRNA)	NM_001161560	NM_001163007
RefSeq (protein)	NP_001155032	NP_001156479
Location (UCSC)	Chr 3: 171.06 – 171.46 Mb	Chr 3: 28.26 – 28.68 Mb
PubMed search

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.^[1][2][3]

Function

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.^[2][3]

Interactions

TNIK has been shown to interact with KIAA0090,^[4] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes.^[2]

References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
2. Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem 274 (43): 30729–37. doi:10.1074/jbc.274.43.30729. PMID 10521462.
3. "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".
4. Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Yonekura H, Migita H, Sakurai S, et al. (1999). "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes.". Nucleic Acids Res. 27 (13): 2591–600. doi:10.1093/nar/27.13.2591. PMC 148466. PMID 10373574.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Taira K, Umikawa M, Takei K, et al. (2005). "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.". J. Biol. Chem. 279 (47): 49488–96. doi:10.1074/jbc.M406370200. PMID 15342639.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.