TNIP1

TNFAIP3 interacting protein 1
Identifiers
Symbols	TNIP1 ; ABIN-1; NAF1; VAN; nip40-1
External IDs	OMIM: 607714 MGI: 1926194 HomoloGene: 31355 GeneCards: TNIP1 Gene
Gene ontology Molecular function • ubiquitin-specific protease activity • protein binding • mitogen-activated protein kinase binding Cellular component • intracellular • nucleus • cytoplasm Biological process • MyD88-dependent toll-like receptor signaling pathway • translation • proteolysis • defense response • inflammatory response • leukocyte cell-cell adhesion • glycoprotein biosynthetic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of viral genome replication • positive regulation of transcription from RNA polymerase II promoter • positive regulation of inflammatory response • negative regulation of ERK1 and ERK2 cascade • modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10318	57783
Ensembl	ENSG00000145901	ENSMUSG00000020400
UniProt	Q15025	Q9WUU8
RefSeq (mRNA)	NM_001252385	NM_001199275
RefSeq (protein)	NP_001239314	NP_001186204
Location (UCSC)	Chr 5: 151.03 – 151.09 Mb	Chr 11: 54.91 – 54.96 Mb
PubMed search

TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.^[1][2][3]

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

• Systemic Sclerosis;^[4]
• Psoriasis;^[5]
• Psoriatic arthritis;^[6]
• Systemic Lupus Erythematosus^[7][8]

Interactions

TNIP1 has been shown to interact with TNFAIP3^[9] and MAPK1.^[10]

References

1. Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Jan 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610.
2. Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Dec 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
3. "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
4. Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (Jul 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLoS Genetics 7 (7): e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
5. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (Feb 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
6. Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases 70 (9): 1641–4. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
7. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (Nov 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics 41 (11): 1228–33. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
8. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (Nov 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics 41 (11): 1234–7. doi:10.1038/ng.472. PMID 19838193.
9. Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
10. Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Loftus SK, Dixon J, Koprivnikar K, Dixon MJ, Wasmuth JJ (Jan 1996). "Transcriptional map of the Treacher Collins candidate gene region". Genome Research 6 (1): 26–34. doi:10.1101/gr.6.1.26. PMID 8681136.
• Jäkel S, Görlich D (Aug 1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". The EMBO Journal 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
• Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
• Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Gallagher J, Howlin J, McCarthy C, Murphy EP, Bresnihan B, FitzGerald O, Godson C, Brady HR, Martin F (Sep 2003). "Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays". FEBS Letters 551 (1-3): 8–12. doi:10.1016/S0014-5793(03)00823-8. PMID 12965196.
• Favre M, Butticaz C, Stevenson B, Jongeneel CV, Telenti A (Oct 2003). "High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML". Journal of Acquired Immune Deficiency Syndromes 34 (2): 127–33. doi:10.1097/00126334-200310010-00002. PMID 14526201.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M, Henry Y (May 2006). "hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase". RNA 12 (5): 832–40. doi:10.1261/rna.2344106. PMC 1440901. PMID 16601202.

External links

• TNIP1 human gene location in the UCSC Genome Browser.
• TNIP1 human gene details in the UCSC Genome Browser.