TNKS2

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Rendering based on PDB 3KR7​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Y0I​, 3KR7​, 3KR8​, 3MHJ​, 3MHK​, 3P0N​, 3P0P​, 3P0Q​, 3TWQ​, 3TWR​, 3TWS​, 3TWT​, 3TWU​, 3TWV​, 3TWW​, 3TWX​, 3U9H​, 3U9Y​, 3UA9​, 3W51​, 4AVU​, 4AVW​, 4BFP​, 4BJ9​, 4BJB​, 4BJC​, 4BS4​, 4BU3​, 4BU5​, 4BU6​, 4BU7​, 4BU8​, 4BU9​, 4BUA​, 4BUD​, 4BUE​, 4BUF​, 4BUI​, 4BUS​, 4BUT​, 4BUU​, 4BUV​, 4BUW​, 4BUX​, 4BUY​, 4HKI​, 4HKK​, 4HKN​, 4HL5​, 4HLF​, 4HLG​, 4HLH​, 4HLK​, 4HLM​, 4HMH​, 4HYF​, 4IUE​, 4J1Z​, 4J21​, 4J22​, 4J3L​, 4J3M​, 4KZL​, 4KZQ​, 4KZU​, 4L09​, 4L0B​, 4L0I​, 4L0S​, 4L0T​, 4L0V​, 4L10​, 4L2F​, 4L2G​, 4L2K​, 4L31​, 4L32​, 4L33​, 4L34​, 4M7B​, 4PML​, 4PNL​, 4PNM​, 4PNN​, 4PNQ​, 4PNR​, 4PNS​, 4PNT​, 4TJU​, 4TJW​, 4TJY​, 4TK0​, 4TK5​, 4TKF​, 4TKG​, 4TKI​
Identifiers
Symbols	TNKS2 ; ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C; TANK2; TNKL; pART6
External IDs	OMIM: 607128 MGI: 1921743 HomoloGene: 11890 ChEMBL: 6154 GeneCards: TNKS2 Gene
EC number	2.4.2.30
Gene ontology Molecular function • NAD+ ADP-ribosyltransferase activity • protein binding • enzyme binding • metal ion binding Cellular component • Golgi membrane • pericentriolar material • nuclear chromosome, telomeric region • nucleus • nuclear envelope • cytoplasm • cytosol • perinuclear region of cytoplasm Biological process • protein polyubiquitination • protein ADP-ribosylation • Wnt signaling pathway • positive regulation of telomere maintenance via telomerase • multicellular organism growth • regulation of multicellular organism growth • protein localization to chromosome, telomeric region • protein auto-ADP-ribosylation • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80351	74493
Ensembl	ENSG00000107854	ENSMUSG00000024811
UniProt	Q9H2K2	Q3UES3
RefSeq (mRNA)	NM_025235	NM_001163635
RefSeq (protein)	NP_079511	NP_001157107
Location (UCSC)	Chr 10: 91.8 – 91.87 Mb	Chr 19: 36.83 – 36.89 Mb
PubMed search

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.^[1]

Interactions

TNKS2 has been shown to interact with GRB14,^[2] TERF1^[3][4][5] and Cystinyl aminopeptidase.^[4][5][6]

References

1. "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2".
2. Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
3. Cook, Brandoch D; Dynek Jasmin N; Chang William; Shostak Grigoriy; Smith Susan (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. (United States) 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745.
4. Chi, N W; Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. (UNITED STATES) 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
5. Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. (England) 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.
6. Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. (United States) 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.

Further reading

• Monz D, Munnia A, Comtesse N, et al. (2001). "Novel tankyrase-related gene detected with meningioma-specific sera.". Clin. Cancer Res. 7 (1): 113–9. PMID 11205898.
• Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.
• Kuimov AN, Kuprash DV, Petrov VN, et al. (2001). "Cloning and characterization of TNKL, a member of tankyrase gene family.". Genes Immun. 2 (1): 52–5. doi:10.1038/sj.gene.6363722. PMID 11294570.
• Kaminker PG, Kim SH, Taylor RD, et al. (2001). "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.". J. Biol. Chem. 276 (38): 35891–9. doi:10.1074/jbc.M105968200. PMID 11454873.
• Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.". Mol. Cell. Biol. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. PMC 134233. PMID 11739745.
• Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).". Biochem. J. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. PMC 1222327. PMID 11802774.
• Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).". J. Biol. Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Deng Z, Atanasiu C, Zhao K, et al. (2005). "Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.". J. Virol. 79 (8): 4640–50. doi:10.1128/JVI.79.8.4640-4650.2005. PMC 1069541. PMID 15795250.
• Sidorova N, Zavalishina L, Kurchashova S, et al. (2006). "Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue.". Cell Tissue Res. 323 (1): 137–45. doi:10.1007/s00441-005-0053-8. PMID 16151859.