TNS1

Tensin 1
Identifiers
Symbols	TNS1 ; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MXRA6; PPP1R155; TNS
External IDs	OMIM: 600076 MGI: 104552 HomoloGene: 11219 GeneCards: TNS1 Gene
Gene ontology Molecular function • actin binding • protein binding • poly(A) RNA binding Cellular component • cytoplasm • cytoskeleton • focal adhesion • cell surface Biological process • cell-substrate junction assembly • fibroblast migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7145	21961
Ensembl	ENSG00000079308	ENSMUSG00000055322
UniProt	Q9HBL0	E9Q0S6
RefSeq (mRNA)	NM_001308022	NM_001289895
RefSeq (protein)	NP_001294951	NP_001276824
Location (UCSC)	Chr 2: 217.8 – 218 Mb	Chr 1: 73.91 – 74.12 Mb
PubMed search

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.^[1]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.^[1]

External links

• TNS1 Info with links in the Cell Migration Gateway

References

1. "Entrez Gene: TNS1 tensin 1".

Further reading

• Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1.". Mamm. Genome 6 (10): 744–5. doi:10.1007/BF00354299. PMID 8563175.
• Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Katz BZ, Zohar M, Teramoto H, et al. (2000). "Tensin can induce JNK and p38 activation.". Biochem. Biophys. Res. Commun. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821.
• Chen H, Ishii A, Wong WK, et al. (2001). "Molecular characterization of human tensin.". Biochem. J. 351 Pt 2: 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826.
• Benzing T, Gerke P, Höpker K, et al. (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9784–9. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamashita M, Horikoshi S, Asanuma K, et al. (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells.". Histochem. Cell Biol. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Eto M, Kirkbride J, Elliott E, et al. (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions.". J. Biol. Chem. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217.