TOPORS

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Identifiers
Symbols	TOPORS ; LUN; P53BP3; RP31; TP53BPL
External IDs	OMIM: 609507 MGI: 2146189 HomoloGene: 4237 GeneCards: TOPORS Gene
Gene ontology Molecular function • DNA binding • antigen binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • SUMO transferase activity • DNA topoisomerase binding • ubiquitin protein ligase activity Cellular component • ubiquitin ligase complex • spindle pole • gamma-tubulin complex • nucleus • centriole • cytoplasmic dynein complex • PML body • nuclear speck • midbody • photoreceptor connecting cilium • ciliary basal body Biological process • transcription, DNA-templated • ubiquitin-dependent protein catabolic process • protein monoubiquitination • cellular response to DNA damage stimulus • intrinsic apoptotic signaling pathway in response to DNA damage • retina layer formation • protein sumoylation • protein localization to nucleus • photoreceptor cell outer segment organization • regulation of cell proliferation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of apoptotic process • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of transcription, DNA-templated • retinal rod cell development • retinal cone cell development • positive regulation of ubiquitin-protein transferase activity • maintenance of protein location in nucleus • protein K48-linked ubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10210	106021
Ensembl	ENSG00000197579	ENSMUSG00000036822
UniProt	Q9NS56	Q80Z37
RefSeq (mRNA)	NM_001195622	NM_134097
RefSeq (protein)	NP_001182551	NP_598858
Location (UCSC)	Chr 9: 32.54 – 32.55 Mb	Chr 4: 40.26 – 40.27 Mb
PubMed search

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.^[1][2][3][4]

References

1. Haluska P Jr, Saleem A, Rasheed Z, Ahmed F, Su EW, Liu LF, Rubin EH (Jul 1999). "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein". Nucleic Acids Res 27 (12): 2538–44. doi:10.1093/nar/27.12.2538. PMC 148458. PMID 10352183.
2. Rasheed ZA, Saleem A, Ravee Y, Pandolfi PP, Rubin EH (Jun 2002). "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies". Exp Cell Res 277 (2): 152–60. doi:10.1006/excr.2002.5550. PMID 12083797.
3. Chakarova CF, Papaioannou MG, Khanna H, Lopez I, Waseem N, Shah A, Theis T, Friedman J, Maubaret C, Bujakowska K, Veraitch B, Abd El-Aziz MM, Prescott de Q, Parapuram SK, Bickmore WA, Munro PM, Gal A, Hamel CP, Marigo V, Ponting CP, Wissinger B, Zrenner E, Matter K, Swaroop A, Koenekoop RK, Bhattacharya SS (Oct 2007). "Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy". Am J Hum Genet 81 (5): 1098–103. doi:10.1086/521953. PMC 2265653. PMID 17924349.
4. "Entrez Gene: TOPORS topoisomerase I binding, arginine/serine-rich".

Further reading

• Zhou R, Wen H, Ao SZ (1999). "Identification of a novel gene encoding a p53-associated protein.". Gene 235 (1–2): 93–101. doi:10.1016/S0378-1119(99)00203-6. PMID 10415337.
• Souto-Carneiro MM, Krenn V, Hermann R, et al. (2001). "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Res. 2 (4): 303–14. doi:10.1186/ar105. PMC 17813. PMID 11056671.
• Chu D, Kakazu N, Gorrin-Rivas MJ, et al. (2001). "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence". J. Biol. Chem. 276 (17): 14004–13. doi:10.1074/jbc.M010262200. PMID 11278651.
• Weger S, Hammer E, Heilbronn R (2002). "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression". J. Gen. Virol. 83 (Pt 3): 511–6. PMID 11842245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Weger S, Hammer E, Engstler M (2003). "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation". Exp. Cell Res. 290 (1): 13–27. doi:10.1016/S0014-4827(03)00292-1. PMID 14516784.
• Saleem A, Dutta J, Malegaonkar D, et al. (2004). "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor". Oncogene 23 (31): 5293–300. doi:10.1038/sj.onc.1207700. PMID 15107820.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rajendra R, Malegaonkar D, Pungaliya P, et al. (2004). "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53". J. Biol. Chem. 279 (35): 36440–4. doi:10.1074/jbc.C400300200. PMID 15247280.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Oyanagi H, Takenaka K, Ishikawa S, et al. (2005). "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer". Lung Cancer 46 (1): 21–8. doi:10.1016/j.lungcan.2004.03.009. PMID 15364129.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Flatten K, Dai NT, Vroman BT, et al. (2005). "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons". J. Biol. Chem. 280 (14): 14349–55. doi:10.1074/jbc.M411890200. PMID 15699047.
• Lin L, Ozaki T, Takada Y, et al. (2005). "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene 24 (21): 3385–96. doi:10.1038/sj.onc.1208554. PMID 15735665.
• Weger S, Hammer E, Heilbronn R (2005). "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo". FEBS Lett. 579 (22): 5007–12. doi:10.1016/j.febslet.2005.07.088. PMID 16122737.
• Papaioannou M, Chakarova CF, Prescott DC, et al. (2006). "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p". Hum. Genet. 118 (3–4): 501–3. doi:10.1007/s00439-005-0063-3. PMID 16189705.

External links

• TOPORS human gene location in the UCSC Genome Browser.
• TOPORS human gene details in the UCSC Genome Browser.