TPPP
| Tubulin polymerization promoting protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TPPP ; TPPP/p25; TPPP1; p24; p25; p25alpha | ||||||||||||
| External IDs | OMIM: 608773 MGI: 1920198 HomoloGene: 21389 GeneCards: TPPP Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11076 | 72948 | |||||||||||
| Ensembl | ENSG00000171368 | ENSMUSG00000021573 | |||||||||||
| UniProt | O94811 | Q7TQD2 | |||||||||||
| RefSeq (mRNA) | NM_007030 | NM_182839 | |||||||||||
| RefSeq (protein) | NP_008961 | NP_878259 | |||||||||||
| Location (UCSC) |
Chr 5: 0.66 – 0.69 Mb |
Chr 13: 74.01 – 74.04 Mb | |||||||||||
| PubMed search | |||||||||||||
Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[1][2][3][4][5]
This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[6]
References
- ↑ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.
- ↑ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.
- ↑ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.
- ↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.
- ↑ "Entrez Gene: TPPP brain-specific protein p25 alpha".
- ↑ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor.". Biochim. Biophys. Acta 1586 (1): 113–22. doi:10.1016/s0925-4439(01)00092-8. PMID 11781156.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. doi:10.1073/pnas.2436331100. PMC 283531. PMID 14623963.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival.". J. Cell. Sci. 117 (Pt 25): 6249–59. doi:10.1242/jcs.01550. PMID 15564385.
- DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
- Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells.". Biochem. Biophys. Res. Commun. 345 (1): 324–31. doi:10.1016/j.bbrc.2006.04.032. PMID 16678793.
- Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain.". J. Neurochem. 99 (1): 333–42. doi:10.1111/j.1471-4159.2006.04073.x. PMID 16879710.
- Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.". FEBS Lett. 580 (25): 5807–14. doi:10.1016/j.febslet.2006.09.037. PMID 17027006.
- Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases.". J. Biol. Chem. 282 (40): 29531–9. doi:10.1074/jbc.M703466200. PMID 17693641.
- Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.". Am. J. Pathol. 171 (4): 1291–303. doi:10.2353/ajpath.2007.070201. PMC 1988878. PMID 17823288.
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