TRAF interacting protein

TRAF interacting protein
Identifiers
Symbols	TRAIP ; RNF206; TRIP
External IDs	OMIM: 605958 MGI: 1096377 HomoloGene: 31343 GeneCards: TRAIP Gene
Gene ontology Molecular function • receptor signaling protein activity • protein binding • zinc ion binding • ligase activity • ubiquitin protein ligase activity Cellular component • nucleolus • perinuclear region of cytoplasm Biological process • apoptotic process • signal transduction • cell proliferation • negative regulation of tumor necrosis factor-mediated signaling pathway • protein ubiquitination • negative regulation of interferon-beta production • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10293	22036
Ensembl	ENSG00000183763	ENSMUSG00000032586
UniProt	Q9BWF2	Q8VIG6
RefSeq (mRNA)	NM_005879	NM_011634
RefSeq (protein)	NP_005870	NP_035764
Location (UCSC)	Chr 3: 49.83 – 49.86 Mb	Chr 9: 107.95 – 107.97 Mb
PubMed search

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.^[1][2]

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.^[2]

Interactions

TRAF interacting protein has been shown to interact with FLII,^[3] TRAF1^[1] and TRAF2.^[1]

References

1. Lee SY, Lee SY, Choi Y (May 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". J Exp Med 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
2. "Entrez Gene: TRAIP TRAF interacting protein".
3. Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. (ENGLAND) 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Further reading

• Beckly JB, Hancock L, Geremia A, et al. (2008). "Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease.". Inflamm. Bowel Dis. 14 (4): 500–7. doi:10.1002/ibd.20365. PMID 18200509.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Regamey A, Hohl D, Liu JW, et al. (2004). "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.". J. Exp. Med. 198 (12): 1959–64. doi:10.1084/jem.20031187. PMC 2194148. PMID 14676304.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• TRAIP human gene location in the UCSC Genome Browser.
• TRAIP human gene details in the UCSC Genome Browser.