TREM1

Triggering receptor expressed on myeloid cells 1

PDB rendering based on 1q8m.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TREM1 ; CD354; TREM-1
External IDs OMIM: 605085 MGI: 1930005 HomoloGene: 10243 ChEMBL: 1697674 GeneCards: TREM1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 54210 58217
Ensembl ENSG00000124731 ENSMUSG00000042265
UniProt Q9NP99 Q9JKE2
RefSeq (mRNA) NM_001242589 NM_021406
RefSeq (protein) NP_001229518 NP_067381
Location (UCSC) Chr 6:
41.27 – 41.29 Mb		 Chr 17:
48.23 – 48.25 Mb
PubMed search

Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene.[1][2][3]

Function

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM][3]

Model organisms

Model organisms have been used in the study of TREM1 function. A conditional knockout mouse line called Trem1tm1(KOMP)Vlcg was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]

References

  1. ↑ Gingras MC, Lapillonne H, Margolin JF (Mar 2002). "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development". Molecular Immunology 38 (11): 817–24. doi:10.1016/S0161-5890(02)00004-4. PMID 11922939.
  2. ↑ Bouchon A, Dietrich J, Colonna M (May 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology 164 (10): 4991–5. doi:10.4049/jimmunol.164.10.4991. PMID 10799849.
  3. 1 2 "Entrez Gene: TREM1 triggering receptor expressed on myeloid cells 1".
  4. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  5. 1 2 "International Mouse Phenotyping Consortium".
  6. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  7. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  8. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  9. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  10. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Bouchon A, Facchetti F, Weigand MA, Colonna M (Apr 2001). "TREM-1 amplifies inflammation and is a crucial mediator of septic shock". Nature 410 (6832): 1103–7. doi:10.1038/35074114. PMID 11323674. 
  • Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (Feb 2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". European Journal of Immunology 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956. 
  • Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, Modlin RL (Apr 2003). "A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response". Journal of Immunology 170 (7): 3812–8. doi:10.4049/jimmunol.170.7.3812. PMID 12646648. 
  • Colonna M, Facchetti F (Jun 2003). "TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses". The Journal of Infectious Diseases. 187 Suppl 2: S397–401. doi:10.1086/374754. PMID 12792857. 
  • Radaev S, Kattah M, Rostro B, Colonna M, Sun PD (Dec 2003). "Crystal structure of the human myeloid cell activating receptor TREM-1". Structure 11 (12): 1527–35. doi:10.1016/j.str.2003.11.001. PMID 14656437. 
  • Radsak MP, Salih HR, Rammensee HG, Schild H (Apr 2004). "Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival". Journal of Immunology 172 (8): 4956–63. doi:10.4049/jimmunol.172.8.4956. PMID 15067076. 
  • Wang DY, Qin RY, Liu ZR, Gupta MK, Chang Q (Sep 2004). "Expression of TREM-1 mRNA in acute pancreatitis". World Journal of Gastroenterology 10 (18): 2744–6. PMID 15309732. 
  • Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA (Sep 2004). "Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A". Journal of Molecular Biology 342 (4): 1237–48. doi:10.1016/j.jmb.2004.07.089. PMID 15351648. 
  • Knapp S, Gibot S, de Vos A, Versteeg HH, Colonna M, van der Poll T (Dec 2004). "Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia". Journal of Immunology 173 (12): 7131–4. doi:10.4049/jimmunol.173.12.7131. PMID 15585833. 
  • González-Roldán N, Ferat-Osorio E, Aduna-Vicente R, Wong-Baeza I, Esquivel-Callejas N, Astudillo-de la Vega H, Sánchez-Fernández P, Arriaga-Pizano L, Villasís-Keever MA, López-Macías C, Isibasi A (Dec 2005). "Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery". World Journal of Gastroenterology 11 (47): 7473–9. PMID 16437719. 
  • Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, Tzivras D, Tsaganos T, Koutoukas P, Giamarellou H, Archimandritis A (Jun 2006). "Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease". World Journal of Gastroenterology 12 (21): 3416–9. PMID 16733861. 
  • Plachouras D, Routsi C, Giamarellos-Bourboulis EJ, Spyridaki E, Andrianakis I, Metzelopoulos S, Tsaganos T, Floros I, Douzinas EE, Armaganidis A, Roussos C, Giamarellou H (2006). "Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the septic host". Scandinavian Journal of Infectious Diseases 38 (10): 909–15. doi:10.1080/00365540600786523. PMID 17008237. 
  • Murakami Y, Kohsaka H, Kitasato H, Akahoshi T (Jan 2007). "Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2". Journal of Immunology 178 (2): 1144–50. doi:10.4049/jimmunol.178.2.1144. PMID 17202378. 
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