TREML1

Triggering receptor expressed on myeloid cells-like 1
PDB rendering based on 2frg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FRG​
Identifiers
Symbols	TREML1 ; GLTL1825; PRO3438; TLT-1; TLT1; dJ238O23.3
External IDs	OMIM: 609714 MGI: 1918576 HomoloGene: 52257 GeneCards: TREML1 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • plasma membrane • cell surface • integral component of membrane • platelet alpha granule Biological process • calcium-mediated signaling • platelet activation • innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340205	71326
Ensembl	ENSG00000161911	ENSMUSG00000023993
UniProt	Q86YW5	Q8K558
RefSeq (mRNA)	NM_001271807	NM_001289451
RefSeq (protein)	NP_001258736	NP_001276380
Location (UCSC)	Chr 6: 41.15 – 41.15 Mb	Chr 17: 48.36 – 48.37 Mb
PubMed search

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.^[1][2][3]

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004).[supplied by OMIM]^[3]

References

1. Washington AV, Quigley L, McVicar DW (Nov 2002). "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster". Blood 100 (10): 3822–4. doi:10.1182/blood-2002-02-0523. PMID 12393607.
2. Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (Mar 2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur J Immunol 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956.
3. "Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Washington AV, Schubert RL, Quigley L, et al. (2005). "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.". Blood 104 (4): 1042–7. doi:10.1182/blood-2004-01-0315. PMID 15100151.
• Barrow AD, Astoul E, Floto A, et al. (2004). "Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.". J. Immunol. 172 (10): 5838–42. doi:10.4049/jimmunol.172.10.5838. PMID 15128762.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gattis JL, Washington AV, Chisholm MM, et al. (2006). "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.". J. Biol. Chem. 281 (19): 13396–403. doi:10.1074/jbc.M600489200. PMID 16505478.
• Giomarelli B, Washington VA, Chisholm MM, et al. (2007). "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.". Thromb. Haemost. 97 (6): 955–63. doi:10.1160/th06-08-0456. PMID 17549298.