TRERF1

Transcriptional regulating factor 1
Identifiers
Symbols	TRERF1 ; BCAR2; HSA277276; RAPA; TREP132; TReP-132; dJ139D8.5
External IDs	OMIM: 610322 MGI: 2442086 HomoloGene: 14129 GeneCards: TRERF1 Gene
Gene ontology Molecular function • RNA polymerase II transcription cofactor activity • transcription factor activity, sequence-specific DNA binding • transcription factor binding • DNA binding, bending • ligand-dependent nuclear receptor transcription coactivator activity • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • steroid biosynthetic process • cholesterol catabolic process • multicellular organismal development • homeostatic process • positive regulation of transcription, DNA-templated • regulation of hormone biosynthetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55809	224829
Ensembl	ENSG00000124496	ENSMUSG00000064043
UniProt	Q96PN7	Q8BXJ2
RefSeq (mRNA)	NM_001297573	NM_001097623
RefSeq (protein)	NP_001284502	NP_001091092
Location (UCSC)	Chr 6: 42.22 – 42.45 Mb	Chr 17: 47.14 – 47.36 Mb
PubMed search

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.^[1][2]

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.^[2]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,^[3] EP300^[1] and CREB-binding protein.^[1]

References

1. Gizard F, Lavallee B, DeWitte F, Hum DW (Sep 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". J Biol Chem 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
2. "Entrez Gene: TRERF1 transcriptional regulating factor 1".
3. Gizard, Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W (Oct 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". J. Biol. Chem. (United States) 277 (42): 39144–55. doi:10.1074/jbc.M205786200. ISSN 0021-9258. PMID 12101186.

Further reading

• Dorssers LC, Veldscholte J (1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells.". Int. J. Cancer 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413.
• Gizard F, Lavallee B, DeWitte F, et al. (2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.". J. Biol. Chem. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
• Gizard F, El-Alfy M, Duguay Y, et al. (2003). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.". Endocr. Res. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gizard F, Teissier E, Dufort I, et al. (2005). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.". J. Mol. Endocrinol. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gizard F, Robillard R, Barbier O, et al. (2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.". Mol. Cell. Biol. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840.
• Gizard F, Robillard R, Gross B, et al. (2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.". Mol. Cell. Biol. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480.