TRIM15

Tripartite motif containing 15
Identifiers
Symbols	TRIM15 ; RNF93; ZNF178; ZNFB7
External IDs	MGI: 1916347 HomoloGene: 23819 GeneCards: TRIM15 Gene
Gene ontology Molecular function • protein binding • zinc ion binding Cellular component • intracellular Biological process • mesodermal cell fate determination • positive regulation of type I interferon production • innate immune response • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • positive regulation of RIG-I signaling pathway • negative regulation of intracellular transport of viral material • negative regulation of viral release from host cell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	89870	69097
Ensembl	ENSG00000137384	ENSMUSG00000050747
UniProt	Q9C019	Q8R096
RefSeq (mRNA)	NM_033229	NM_001024134
RefSeq (protein)	NP_150232	NP_001019305
Location (UCSC)	Chr 6: 30.16 – 30.17 Mb	Chr 17: 36.86 – 36.87 Mb
PubMed search

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.^[1][2][3][4]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[4]

References

1. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
2. Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet 54 (2): 244–51. PMC 1918154. PMID 8304341.
3. Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
4. "Entrez Gene: TRIM15 tripartite motif-containing 15".

Further reading

• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity". Genetics 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells". Mol. Cell. Biol. 19 (5): 3808–15. PMC 84222. PMID 10207104.