TRIM16
| Tripartite motif containing 16 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TRIM16 ; EBBP | ||||||||||||
| External IDs | OMIM: 609505 MGI: 2137356 HomoloGene: 4726 GeneCards: TRIM16 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10626 | 94092 | |||||||||||
| Ensembl | ENSG00000221926 | ENSMUSG00000047821 | |||||||||||
| UniProt | O95361 | Q99PP9 | |||||||||||
| RefSeq (mRNA) | NM_006470 | NM_053169 | |||||||||||
| RefSeq (protein) | NP_006461 | NP_444399 | |||||||||||
| Location (UCSC) |
Chr 17: 15.63 – 15.68 Mb |
Chr 11: 62.82 – 62.85 Mb | |||||||||||
| PubMed search | |||||||||||||
Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.[1][2]
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.[2]
References
- ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- 1 2 "Entrez Gene: TRIM16 tripartite motif-containing 16".
Further reading
- Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant". Mol. Endocrinol. 12 (11): 1733–48. doi:10.1210/me.12.11.1733. PMID 9817599.
- Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation". J. Biol. Chem. 277 (23): 20740–9. doi:10.1074/jbc.M111233200. PMID 11919186.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion". Cell Death Differ. 13 (11): 1938–49. doi:10.1038/sj.cdd.4401896. PMID 16575408.
- Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal". J. Biol. Chem. 281 (26): 18246–56. doi:10.1074/jbc.M600879200. PMID 16636064.
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