TRIM37

Tripartite motif containing 37
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LRQ​
Identifiers
Symbols	TRIM37 ; MUL; POB1; TEF3
External IDs	OMIM: 605073 MGI: 2153072 HomoloGene: 9084 GeneCards: TRIM37 Gene
Gene ontology Molecular function • chromatin binding • ubiquitin-protein transferase activity • tumor necrosis factor receptor binding • protein binding • zinc ion binding • ligase activity • ubiquitin protein ligase binding • protein homodimerization activity • ubiquitin protein ligase activity Cellular component • cytoplasm • peroxisome • cytosol • aggresome • ESC/E(Z) complex • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • histone H2A monoubiquitination • histone H2A-K119 monoubiquitination • negative regulation of centriole replication • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • protein autoubiquitination • aggresome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4591	68729
Ensembl	ENSG00000108395	ENSMUSG00000018548
UniProt	O94972	Q6PCX9
RefSeq (mRNA)	NM_001005207	NM_197987
RefSeq (protein)	NP_001005207	NP_932104
Location (UCSC)	Chr 17: 58.98 – 59.11 Mb	Chr 11: 87.13 – 87.22 Mb
PubMed search

Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.^[1][2][3]

Function

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein–protein and/or protein–nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.^[3]

Interactions

TRIM37 has been shown to interact with PRC1.^[4]

See also

• Mulibrey nanism

References

1. Avela K, Lipsanen-Nyman M, Perheentupa J, Wallgren-Pettersson C, Marchand S, Fauré S, Sistonen P, de la Chapelle A, Lehesjoki AE (Apr 1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis". American Journal of Human Genetics 60 (4): 896–902. PMC 1712467. PMID 9106536.
2. Avela K, Lipsanen-Nyman M, Idänheimo N, Seemanová E, Rosengren S, Mäkelä TP, Perheentupa J, Chapelle AD, Lehesjoki AE (Jul 2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nature Genetics 25 (3): 298–301. doi:10.1038/77053. PMID 10888877.
3. "Entrez Gene: TRIM37 tripartite motif-containing 37".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
• Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND (Oct 2001). "Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis". Mechanisms of Development 108 (1-2): 221–5. doi:10.1016/S0925-4773(01)00491-9. PMID 11578880.
• Kallijärvi J, Avela K, Lipsanen-Nyman M, Ulmanen I, Lehesjoki AE (May 2002). "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder". American Journal of Human Genetics 70 (5): 1215–28. doi:10.1086/340256. PMC 447596. PMID 11938494.
• Jagiello P, Hammans C, Wieczorek S, Arning L, Stefanski A, Strehl H, Epplen JT, Gencik M (Jun 2003). "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity". Human Mutation 21 (6): 630–5. doi:10.1002/humu.10220. PMID 12754710.
• Hämäläinen RH, Avela K, Lambert JA, Kallijärvi J, Eyaid W, Gronau J, Ignaszewski AP, McFadden D, Sorge G, Lipsanen-Nyman M, Lehesjoki AE (May 2004). "Novel mutations in the TRIM37 gene in Mulibrey Nanism". Human Mutation 23 (5): 522. doi:10.1002/humu.9233. PMID 15108285.
• Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE (Aug 2005). "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase". Experimental Cell Research 308 (1): 146–55. doi:10.1016/j.yexcr.2005.04.001. PMID 15885686.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Karlberg N, Jalanko H, Kallijärvi J, Lehesjoki AE, Lipsanen-Nyman M (Dec 2005). "Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37". Diabetes 54 (12): 3577–81. doi:10.2337/diabetes.54.12.3577. PMID 16306379.
• Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE (Jan 2006). "Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing". Gene 366 (1): 180–8. doi:10.1016/j.gene.2005.08.008. PMID 16310976.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Hämäläinen RH, Mowat D, Gabbett MT, O'brien TA, Kallijärvi J, Lehesjoki AE (Dec 2006). "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism". Clinical Genetics 70 (6): 473–9. doi:10.1111/j.1399-0004.2006.00700.x. PMID 17100991.
• Doğanc T, Yüksel Konuk BE, Alpan N, Konuk O, Hämäläinen RH, Lehesjoki AE, Tekin M (Jul 2007). "A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy". Clinical Dysmorphology 16 (3): 173–6. doi:10.1097/MCD.0b013e3280f6d00b. PMID 17551331.