TRIM45

Tripartite motif containing 45
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TRIM45 ; RNF99
External IDs OMIM: 609318 HomoloGene: 11865 GeneCards: TRIM45 Gene
Orthologs
Species Human Mouse
Entrez 80263 229644
Ensembl ENSG00000134253 ENSMUSG00000033233
UniProt Q9H8W5 Q6PFY8
RefSeq (mRNA) NM_001145635 NM_001165952
RefSeq (protein) NP_001139107 NP_001159424
Location (UCSC) Chr 1:
117.11 – 117.12 Mb		 Chr 3:
100.92 – 100.94 Mb
PubMed search

tripartite motif containing 45, also known as TRIM45, is a human gene.[1]

This gene encodes a member of the tripartite motif family. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[1]

Model organisms

Model organisms have been used in the study of TRIM45 function. A conditional knockout mouse line, called Trim45tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on mutant mice and three significant abnormalities were observed.[5] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; males had increased circulating magnesium levels while animals of both sex displayed increased bone strength.[5]

References

  1. 1 2 "Entrez Gene: tripartite motif containing 45". Retrieved 2011-08-30.
  2. ↑ "Clinical chemistry data for Trim45". Wellcome Trust Sanger Institute.
  3. ↑ "Salmonella infection data for Trim45". Wellcome Trust Sanger Institute.
  4. ↑ "Citrobacter infection data for Trim45". Wellcome Trust Sanger Institute.
  5. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ↑ "International Knockout Mouse Consortium".
  8. ↑ "Mouse Genome Informatics".
  9. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

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