TRIM69

tripartite motif containing 69
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NQJ
Identifiers
Aliases	TRIM69, HSD-34, HSD34, RNF36, Trif
External IDs	MGI: 1918178 HomoloGene: 18827 GeneCards: 140691
Gene ontology Molecular function • ubiquitin-protein transferase activity • zinc ion binding • ligase activity • protein binding • metal ion binding Cellular component • cytoplasm • plasma membrane • nuclear speck • intracellular • cell nucleus Biological process • protein ubiquitination • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140691	70928
Ensembl	n/a	ENSMUSG00000033368
UniProt	Q86WT6	Q80X56
RefSeq (mRNA)	NM_182985 NM_001301144 NM_001301145 NM_001301146 NM_080745	NM_080510 XM_006500173
RefSeq (protein)	NP_001288073.1 NP_001288074.1 NP_001288075.1 NP_542783.2 NP_892030.3	NP_536771.2
Location (UCSC)	Chr 15: 44.73 – 44.77 Mb	Chr 2: 122.16 – 122.18 Mb
PubMed search
Wikidata

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Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. ^[1]

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References

1. "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.