TRIP4

Thyroid hormone receptor interactor 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E5O​
Identifiers
Symbols	TRIP4 ; ASC-1; ASC1; HsT17391; ZC2HC5
External IDs	OMIM: 604501 MGI: 1928469 HomoloGene: 9426 GeneCards: TRIP4 Gene
Gene ontology Molecular function • protease binding • transcription coactivator activity • protein binding • zinc ion binding • ligand-dependent nuclear receptor binding • estrogen receptor binding • histone acetyltransferase binding • ubiquitin-like protein ligase binding Cellular component • nucleus • nucleoplasm • cytoplasm • microtubule organizing center • cytosol Biological process • transcription from RNA polymerase II promoter • intracellular estrogen receptor signaling pathway • positive regulation of transcription, DNA-templated • toxin transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9325	56404
Ensembl	ENSG00000103671	ENSMUSG00000032386
UniProt	Q15650	Q9QXN3
RefSeq (mRNA)	NM_016213	NM_001170907
RefSeq (protein)	NP_057297	NP_001164378
Location (UCSC)	Chr 15: 64.39 – 64.46 Mb	Chr 9: 65.83 – 65.91 Mb
PubMed search

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.^[1][2]

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.^[3]

References

1. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
2. "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
3. Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. PMC 84603. PMID 10454579.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1.". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
• Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.". Mol. Cell. Biol. 19 (9): 6323–32. PMC 84603. PMID 10454579.