TRIP6

Thyroid hormone receptor interactor 6
PDB rendering based on 1x61.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X61​, 2DLO​
Identifiers
Symbols	TRIP6 ; OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1
External IDs	OMIM: 602933 MGI: 1343458 HomoloGene: 37757 GeneCards: TRIP6 Gene
Gene ontology Molecular function • interleukin-1 receptor binding • protein binding • zinc ion binding • kinase binding • poly(A) RNA binding • thyroid hormone receptor binding Cellular component • nucleus • cytoplasm • cytoskeleton • plasma membrane • focal adhesion • interleukin-1 receptor complex Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • release of cytoplasmic sequestered NF-kappaB • positive regulation of cell migration • focal adhesion assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7205	22051
Ensembl	ENSG00000087077	ENSMUSG00000023348
UniProt	Q15654	Q9Z1Y4
RefSeq (mRNA)	NM_003302	NM_011639
RefSeq (protein)	NP_003293	NP_035769
Location (UCSC)	Chr 7: 100.87 – 100.87 Mb	Chr 5: 137.31 – 137.31 Mb
PubMed search

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.^[1][2][3]

Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[3]

Interactions

TRIP6 has been shown to interact with LPAR2,^[4] BCAR1^[4][5] and HOXA9.^[6]

References

1. Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321.
2. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
3. "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6".
4. Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.
5. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Williams JM, Chen GC, Zhu L, Rest RF (Jan 1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Molecular Microbiology 27 (1): 171–86. doi:10.1046/j.1365-2958.1998.00670.x. PMID 9466265.
• Murthy KK, Clark K, Fortin Y, Shen SH, Banville D (Jul 1999). "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". The Journal of Biological Chemistry 274 (29): 20679–87. doi:10.1074/jbc.274.29.20679. PMID 10400701.
• Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD (2000). "LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor". Gene Expression 8 (4): 207–17. PMID 10794523.
• Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B, Hendriks W (Apr 2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". European Journal of Cell Biology 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.
• Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, Koop BF (Mar 2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Research 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
• Wang Y, Gilmore TD (Apr 2001). "LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains". Biochimica Et Biophysica Acta 1538 (2-3): 260–72. doi:10.1016/S0167-4889(01)00077-5. PMID 11336797.
• Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
• Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (Feb 2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biology of Reproduction 68 (2): 543–52. doi:10.1095/biolreprod.102.009076. PMC 3158802. PMID 12533418.
• Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.
• Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, Banville D, Vary CP, Bernabéu C (Jul 2004). "Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins". The Journal of Biological Chemistry 279 (31): 32858–68. doi:10.1074/jbc.M400843200. PMID 15148318.
• Kassel O, Schneider S, Heilbock C, Litfin M, Göttlicher M, Herrlich P (Oct 2004). "A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters". Genes & Development 18 (20): 2518–28. doi:10.1101/gad.322404. PMC 529539. PMID 15489293.
• Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB (Feb 2005). "TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways". Journal of Cell Science 118 (Pt 3): 555–63. doi:10.1242/jcs.01641. PMID 15657077.
• Petit MM, Crombez KR, Vervenne HB, Weyns N, Van de Ven WJ (Sep 2005). "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins". FEBS Letters 579 (22): 5061–8. doi:10.1016/j.febslet.2005.08.012. PMID 16137684.