TSEN15

TSEN15 tRNA splicing endonuclease subunit
PDB rendering based on 2gw6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GW6​
Identifiers
Symbols	TSEN15 ; C1orf19; sen15
External IDs	OMIM: 608756 HomoloGene: 12002 GeneCards: TSEN15 Gene
Gene ontology Molecular function • tRNA-intron endonuclease activity Cellular component • nucleolus Biological process • tRNA splicing, via endonucleolytic cleavage and ligation • mRNA processing • RNA phosphodiester bond hydrolysis, endonucleolytic Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116461	66637
Ensembl	ENSG00000198860	ENSMUSG00000014980
UniProt	Q8WW01	Q8R3W5
RefSeq (mRNA)	NM_001127394	NM_025677
RefSeq (protein)	NP_001120866	NP_079953
Location (UCSC)	Chr 1: 184.05 – 184.07 Mb	Chr 1: 152.37 – 152.39 Mb
PubMed search

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[1][2][3]

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[3]

Interactions

C1orf19 has been shown to interact with TSEN2.^[4]

References

1. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
2. Song J, Markley JL (Jan 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". J Mol Biol 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
3. "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
4. Paushkin, Sergey V; Patel Meenal; Furia Bansri S; Peltz Stuart W; Trotta Christopher R (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell (United States) 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. ISSN 0092-8674. PMID 15109492.

Further reading

• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Paushkin SV, Patel M, Furia BS; et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.". Cell 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.