TSEN34
| TSEN34 tRNA splicing endonuclease subunit | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TSEN34 ; LENG5; PCH2C; SEN34; SEN34L | ||||||||||||
| External IDs | OMIM: 608754 MGI: 1913328 HomoloGene: 44182 GeneCards: TSEN34 Gene | ||||||||||||
| EC number | 4.6.1.16 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79042 | 66078 | |||||||||||
| Ensembl | ENSG00000170892 | ENSMUSG00000035585 | |||||||||||
| UniProt | Q9BSV6 | Q8BMZ5 | |||||||||||
| RefSeq (mRNA) | NM_001077446 | NM_001164204 | |||||||||||
| RefSeq (protein) | NP_001070914 | NP_001157676 | |||||||||||
| Location (UCSC) |
Chr 19: 54.19 – 54.19 Mb |
Chr 7: 3.69 – 3.7 Mb | |||||||||||
| PubMed search | |||||||||||||
tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.[1][2][3]
tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][3]
Interactions
TSEN34 has been shown to interact with TSEN2.[2]
References
- ↑ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics 51 (8-9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
- 1 2 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
- 1 2 "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
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