TSSC1

Tumor suppressing subtransferable candidate 1
Identifiers
Symbol	TSSC1
External IDs	OMIM: 608998 MGI: 1289332 HomoloGene: 2481 GeneCards: TSSC1 Gene
Gene ontology Molecular function • protein binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7260	380752
Ensembl	ENSG00000032389	ENSMUSG00000036613
UniProt	Q53HC9	Q8K0G5
RefSeq (mRNA)	NM_003310	NM_201357
RefSeq (protein)	NP_003301	NP_958745
Location (UCSC)	Chr 2: 3.19 – 3.38 Mb	Chr 12: 28.75 – 28.87 Mb
PubMed search

Protein TSSC1 is a protein that in humans is encoded by the TSSC1 gene.^[1][2][3]

This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene may reside on chromosome 2 rather than chromosome 11.^[3]

References

1. Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP (Jan 1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
2. Scelfo R, Sabbioni S, Barbanti-Brodano G, Negrini M; Barbanti-Brodano (Mar 1999). "Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster". Cytogenet Cell Genet 83 (1–2): 52–3. doi:10.1159/000015123. PMID 9925925. Missing |last2= in Authors list (help)
3. "Entrez Gene: TSSC1 tumor suppressing subtransferable candidate 1".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.