TTC3

Tetratricopeptide repeat domain 3
Identifiers
Symbols	TTC3 ; DCRR1; RNF105; TPRDIII
External IDs	OMIM: 602259 MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity Cellular component • nucleus • nucleoplasm • mitochondrion • vacuole Biological process • ubiquitin-dependent protein catabolic process • negative regulation of cell morphogenesis involved in differentiation • negative regulation of neuron differentiation • protein K48-linked ubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7267	22129
Ensembl	ENSG00000182670	ENSMUSG00000040785
UniProt	P53804	G5E8T2
RefSeq (mRNA)	NM_001001894	NM_009441
RefSeq (protein)	NP_001001894	NP_033467
Location (UCSC)	Chr 21: 37.07 – 37.2 Mb	Chr 16: 94.37 – 94.47 Mb
PubMed search

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.^[1][2]

References

1. Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
2. "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Further reading

• Ohira M, Ootsuyama A, Suzuki E, et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
• Eki T, Abe M, Naitou M, et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
• Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
• Rachidi M, Lopes C, Gassanova S, et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Berto G, Camera P, Fusco C, et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell. Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.