TUBA1C

Tubulin, alpha 1c
PDB rendering based on 1ffx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ffx​, 1ia0​, 1jff​, 1sa0​, 1sa1​, 1tub​, 1tvk​, 1z2b​, 2hxf​, 2hxh​
Identifiers
Symbols	TUBA1C ; TUBA6; bcm948
External IDs	MGI: 1095409 HomoloGene: 69045 GeneCards: TUBA1C Gene
Gene ontology Molecular function • GTPase activity • structural molecule activity • structural constituent of cytoskeleton • protein binding • GTP binding Cellular component • nucleus • microtubule • cytoplasmic microtubule • vesicle Biological process • protein folding • microtubule-based process • cytoskeleton-dependent intracellular transport • cellular protein metabolic process • 'de novo' posttranslational protein folding • protein polymerization • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84790	22146
Ensembl	ENSG00000167553	ENSMUSG00000043091
UniProt	Q9BQE3	P68373
RefSeq (mRNA)	NM_001303114	NM_009448
RefSeq (protein)	NP_001290043	NP_033474
Location (UCSC)	Chr 12: 49.19 – 49.27 Mb	Chr 15: 99.03 – 99.04 Mb
PubMed search

Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene.^[1][2]

References

1. Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (Feb 1995). "Construction of a human full-length cDNA bank". Gene 150 (2): 243–250. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
2. "Entrez Gene: TUBA1C tubulin, alpha 1c".

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–320. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". J. Cell Biol. 150 (2): 349–360. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
• Irobi J, Nelis E, Verhoeven K, et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–6810. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
• Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–7075. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
• Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–48204. doi:10.1074/jbc.M406195200. PMID 15331610.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
• Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
• Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, et al. (2006). "Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection". Mol. Biol. Cell 16 (11): 5445–5454. doi:10.1091/mbc.E05-04-0354. PMC 1266439. PMID 16148047.
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Canani RB, De Marco G, Passariello A, et al. (2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells". AIDS 20 (1): 5–10. doi:10.1097/01.aids.0000198088.85572.68. PMID 16327313.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Frum R, Busby SA, Ramamoorthy M, et al. (2007). "HDM2-binding partners: interaction with translation elongation factor EF1alpha". J. Proteome Res. 6 (4): 1410–1417. doi:10.1021/pr060584p. PMID 17373842.