Tubulin beta-4B chain

Tubulin, beta 4B class IVb
PDB rendering based on 1ffx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ffx​, 1ia0​, 1jff​, 1sa0​, 1sa1​, 1tub​, 1tvk​, 1z2b​, 2hxf​, 2hxh​
Identifiers
Symbols	TUBB4B ; Beta2; TUBB2; TUBB2C
External IDs	OMIM: 602660 MGI: 1915472 HomoloGene: 68504 ChEMBL: 1848 GeneCards: TUBB4B Gene
Gene ontology Molecular function • double-stranded RNA binding • GTPase activity • structural constituent of cytoskeleton • GTP binding • MHC class I protein binding • unfolded protein binding Cellular component • nucleus • cytosol • cytoskeleton • microtubule • myelin sheath • extracellular exosome • extracellular vesicle Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • protein folding • movement of cell or subcellular component • organelle organization • microtubule-based process • natural killer cell mediated cytotoxicity • cellular protein metabolic process • 'de novo' posttranslational protein folding • protein polymerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10383	227613
Ensembl	ENSG00000188229	ENSMUSG00000036752
UniProt	P68371	P68372
RefSeq (mRNA)	NM_006088	NM_146116
RefSeq (protein)	NP_006079	NP_666228
Location (UCSC)	Chr 9: 137.24 – 137.24 Mb	Chr 2: 25.22 – 25.22 Mb
PubMed search

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.^[1][2]

References

1. Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
2. "Entrez Gene: TUBB2C tubulin, beta 2C".

Further reading

• Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum". EMBO J. 7 (8): 2311–9. PMC 457095. PMID 2461292.
• Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". J. Cell Biol. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
• Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
• Szalay J, Bruno P, Bhati R, et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells". J. Histochem. Cytochem. 49 (1): 49–66. doi:10.1177/002215540104900106. PMID 11118478.
• Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". J. Immunol. 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
• Walss-Bass C, Xu K, David S, et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579.
• Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
• Dozier JH, Hiser L, Davis JA, et al. (2003). "β class II tubulin predominates in normal and tumor breast tissues". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMC 314434. PMID 12927047.
• Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
• Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
• Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
• Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.

External links

• TUBB4B human gene location in the UCSC Genome Browser.
• TUBB4B human gene details in the UCSC Genome Browser.