TUBE1

Tubulin, epsilon 1
Identifiers
Symbols	TUBE1 ; TUBE; dJ142L7.2
External IDs	OMIM: 607345 HomoloGene: 17762 GeneCards: TUBE1 Gene
Gene ontology Molecular function • GTPase activity • structural constituent of cytoskeleton • GTP binding Cellular component • pericentriolar material • microtubule Biological process • centrosome cycle • metabolic process • protein polymerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51175	71924
Ensembl	ENSG00000074935	ENSMUSG00000019845
UniProt	Q9UJT0	Q9D6T1
RefSeq (mRNA)	NM_016262	NM_028006
RefSeq (protein)	NP_057346	NP_082282
Location (UCSC)	Chr 6: 112.07 – 112.09 Mb	Chr 10: 39.13 – 39.15 Mb
PubMed search

Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene. ^[1] This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication

References

1. "Entrez Gene: Tubulin, epsilon 1". Retrieved 2012-06-06.

Further reading

• Chang, P.; Giddings, T. H.; Winey, M.; Stearns, T. (2002). "Ɛ-Tubulin is required for centriole duplication and microtubule organization". Nature Cell Biology 5 (1): 71–76. doi:10.1038/ncb900. PMID 12510196.
• Zanic, M.; Stear, J. H.; Hyman, A. A.; Howard, J. (2009). May, Robin Charles, ed. "EB1 Recognizes the Nucleotide State of Tubulin in the Microtubule Lattice". PLoS ONE 4 (10): e7585. doi:10.1371/journal.pone.0007585. PMC 2761489. PMID 19851462.
• Stearns, T.; Chang, P. (1999). "Delta-tubulin and epsilon-tubulin: Two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology 2 (1): 30–35. doi:10.1038/71350. PMID 10620804.