TUBG1

Tubulin, gamma 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Z5V​, 1Z5W​, 3CB2​
Identifiers
Symbols	TUBG1 ; CDCBM4; GCP-1; TUBG; TUBGCP1
External IDs	OMIM: 191135 HomoloGene: 833 GeneCards: TUBG1 Gene
Gene ontology Molecular function • GTPase activity • structural constituent of cytoskeleton • protein binding • GTP binding Cellular component • pericentriolar material • condensed nuclear chromosome • gamma-tubulin complex • cytoplasm • centrosome • centriole • polar microtubule • cytosol • cytoplasmic microtubule • cell leading edge • nonmotile primary cilium • ciliary basal body • apical part of cell • recycling endosome Biological process • G2/M transition of mitotic cell cycle • meiotic spindle organization • microtubule cytoskeleton organization • mitotic cell cycle • organelle organization • microtubule nucleation • metabolic process • cytoplasmic microtubule organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7283	103733
Ensembl	ENSG00000131462	ENSMUSG00000035198
UniProt	P23258	P83887
RefSeq (mRNA)	NM_001070	NM_134024
RefSeq (protein)	NP_001061	NP_598785
Location (UCSC)	Chr 17: 42.61 – 42.62 Mb	Chr 11: 101.12 – 101.13 Mb
PubMed search

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. ^[1] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

References

1. "Entrez Gene: Tubulin, gamma 1". Retrieved 2012-06-06.

Further reading

• Zhang, X.; Chen, Q.; Feng, J.; Hou, J.; Yang, F.; Liu, J.; Jiang, Q.; Zhang, C. (2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the TuRC to the centrosome". Journal of Cell Science 122 (13): 2240–2251. doi:10.1242/jcs.042747. PMID 19509060.
• Lau, A. S.; Mruk, D. D. (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology 144 (4): 1549–1563. doi:10.1210/en.2002-220893. PMID 12639940.
• Feng, Y.; Olson, E. C.; Stukenberg, P. T.; Flanagan, L. A.; Kirschner, M. W.; Walsh, C. A. (2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron 28 (3): 665–679. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
• Hsu, L. C.; White, R. L. (1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America 95 (22): 12983–12988. doi:10.1073/pnas.95.22.12983. PMC 23679. PMID 9789027.
• Manning, J. A.; Shalini, S.; Risk, J. M.; Day, C. L.; Kumar, S. (2010). Hotchin, Neil A, ed. "A Direct Interaction with NEDD1 Regulates γ-Tubulin Recruitment to the Centrosome". PLoS ONE 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
• Aldaz, H.; Rice, L. M.; Stearns, T.; Agard, D. A. (2005). "Insights into microtubule nucleation from the crystal structure of human γ-tubulin". Nature 435 (7041): 523–527. doi:10.1038/nature03586. PMID 15917813.
• Niu, Y.; Liu, T.; Tse, G. M. K.; Sun, B.; Niu, R.; Li, H. M.; Wang, H.; Yang, Y.; Ye, X.; Wang, Y.; Yu, Q.; Zhang, F. (2009). "Increased expression of centrosomal α, γ-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science 100 (4): 580–587. doi:10.1111/j.1349-7006.2008.01075.x. PMID 19215229.
• Hampe, C.; Ardila-Osorio, H.; Fournier, M.; Brice, A.; Corti, O. (2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics 15 (13): 2059–2075. doi:10.1093/hmg/ddl131. PMID 16714300.
• Zyss, D.; Montcourrier, P.; Vidal, B.; Anguille, C.; Mérezègue, F.; Sahuquet, A.; Mangeat, P. H.; Coopman, P. J. (2005). "The Syk Tyrosine Kinase Localizes to the Centrosomes and Negatively Affects Mitotic Progression". Cancer Research 65 (23): 10872–10880. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.