TUBGCP3

Tubulin, gamma complex associated protein 3
Identifiers
Symbols	TUBGCP3 ; 104p; GCP3; Grip104; SPBC98; Spc98; Spc98p
External IDs	MGI: 2183752 HomoloGene: 4609 GeneCards: TUBGCP3 Gene
Gene ontology Molecular function • structural molecule activity • structural constituent of cytoskeleton • protein binding • gamma-tubulin binding Cellular component • cytoplasm • centrosome • centriole • spindle • polar microtubule • cytosol • membrane Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • microtubule nucleation • single fertilization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10426	259279
Ensembl	ENSG00000126216	ENSMUSG00000000759
UniProt	Q96CW5	P58854
RefSeq (mRNA)	NM_001286277	NM_198031
RefSeq (protein)	NP_001273206	NP_932148
Location (UCSC)	Chr 13: 112.49 – 112.59 Mb	Chr 8: 12.61 – 12.67 Mb
PubMed search

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene.^[1][2][3] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

• Tubulin
• TUBGCP2
• TUBGCP4
• TUBGCP5
• TUBGCP6

References

1. Murphy SM, Urbani L, Stearns T (Jun 1998). "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p". J Cell Biol 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
2. Tassin AM, Celati C, Moudjou M, Bornens M (Jun 1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J Cell Biol 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.
3. "Entrez Gene: TUBGCP3 tubulin, gamma complex associated protein 3".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.". Mol. Biol. Cell 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: two new members of the human gamma-tubulin complex.". Mol. Biol. Cell 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.