TUSC3

Tumor suppressor candidate 3
Crystal structure of tusc3 thioredoxin domain. PDB entry 4m91​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4M8G​, 4M90​, 4M91​, 4M92​
Identifiers
Symbols	TUSC3 ; D8S1992; M33; MRT22; MRT7; N33; OST3A
External IDs	OMIM: 601385 MGI: 1933134 HomoloGene: 6937 GeneCards: TUSC3 Gene
Gene ontology Molecular function • dolichyl-diphosphooligosaccharide-protein glycotransferase activity • magnesium ion transmembrane transporter activity Cellular component • mitochondrion • endoplasmic reticulum membrane • plasma membrane • integral component of plasma membrane • oligosaccharyltransferase complex Biological process • protein N-linked glycosylation • magnesium ion transport • protein N-linked glycosylation via asparagine • post-translational protein modification • cellular protein metabolic process • cell redox homeostasis • cognition • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7991	80286
Ensembl	ENSG00000104723	ENSMUSG00000039530
UniProt	Q13454	Q8BTV1
RefSeq (mRNA)	NM_006765	NM_030254
RefSeq (protein)	NP_006756	NP_084530
Location (UCSC)	Chr 8: 15.42 – 15.77 Mb	Chr 8: 39.01 – 39.17 Mb
PubMed search

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.^[1][2][3]

This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]

References

1. MacGrogan D, Levy A, Bova GS, Isaacs WB, Bookstein R (Sep 1996). "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22". Genomics 35 (1): 55–65. doi:10.1006/geno.1996.0322. PMID 8661104.
2. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A 96 (7): 3928–33. doi:10.1073/pnas.96.7.3928. PMC 22397. PMID 10097140.
3. "Entrez Gene: TUSC3 tumor suppressor candidate 3".

Further reading

• Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells". Placenta 19 (7): 483–8. doi:10.1016/S0143-4004(98)91041-4. PMID 9778121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Mol. Cell 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Pils D, Horak P, Gleiss A, et al. (2006). "Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival". Cancer 104 (11): 2417–29. doi:10.1002/cncr.21538. PMID 16270321.
• Guervós MA, Marcos CA, Hermsen M, et al. (2007). "Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas". Cell. Oncol. 29 (4): 327–34. PMID 17641416.