TXNL1

Thioredoxin-like 1
PDB rendering based on 1gh2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GH2​, 1WWY​
Identifiers
Symbols	TXNL1 ; HEL-S-114; TRP32; TXL-1; TXNL; Txl
External IDs	OMIM: 603049 MGI: 1860078 HomoloGene: 3515 GeneCards: TXNL1 Gene
Gene ontology Molecular function • protein disulfide oxidoreductase activity • disulfide oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Cellular component • proteasome complex • nucleus • cytoplasm • extracellular exosome Biological process • sulfate assimilation • protein folding • glycerol ether metabolic process • cellular response to oxidative stress • cell redox homeostasis • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9352	53382
Ensembl	ENSG00000091164	ENSMUSG00000024583
UniProt	O43396	Q8CDN6
RefSeq (mRNA)	NM_004786	NM_016792
RefSeq (protein)	NP_004777	NP_058072
Location (UCSC)	Chr 18: 56.6 – 56.65 Mb	Chr 18: 63.66 – 63.69 Mb
PubMed search

Thioredoxin-like protein 1 is a protein that in humans is encoded by the TXNL1 gene.^[1][2][3]

References

1. Miranda-Vizuete A, Gustafsson JA, Spyrou G (Mar 1998). "Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein". Biochem Biophys Res Commun 243 (1): 284–288. doi:10.1006/bbrc.1997.8003. PMID 9473519.
2. Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (Aug 1998). "Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa". J Biol Chem 273 (30): 19160–19166. doi:10.1074/jbc.273.30.19160. PMID 9668102.
3. "Entrez Gene: TXNL1 thioredoxin-like 1".

Further reading

• Miranda-Vizuete A, Spyrou G (2000). "Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl)". DNA Seq. 10 (6): 419–24. doi:10.3109/10425170009015613. PMID 10826702.
• Jin J, Chen X, Zhou Y, et al. (2002). "Crystal structure of the catalytic domain of a human thioredoxin-like protein". Eur. J. Biochem. 269 (8): 2060–2068. doi:10.1046/j.1432-1033.2002.02844.x. PMID 11985582.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim KY, Lee JW, Park MS, et al. (2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)". Int. J. Cancer 118 (7): 1670–1679. doi:10.1002/ijc.21572. PMID 16231315.
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Jiménez A, Pelto-Huikko M, Gustafsson JA, Miranda-Vizuete A (2006). "Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation". FEBS Lett. 580 (3): 960–967. doi:10.1016/j.febslet.2006.01.025. PMID 16438969.