TXNL4A

Thioredoxin-like 4A
PDB rendering based on 1pqn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1PQN​, 1QGV​, 1SYX​, 4BWQ​, 4BWS​, 4CDO​
Identifiers
Symbols	TXNL4A ; BMKS; DIB1; DIM1; SNRNP15; TXNL4; U5-15kD
External IDs	OMIM: 611595 MGI: 1351613 HomoloGene: 7150 GeneCards: TXNL4A Gene
Gene ontology Molecular function • protein binding Cellular component • nucleoplasm • spliceosomal complex • U5 snRNP • U4/U6 x U5 tri-snRNP complex Biological process • spliceosomal complex assembly • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • mitotic nuclear division • RNA splicing • gene expression • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10907	27366
Ensembl	ENSG00000141759	ENSMUSG00000057130
UniProt	P83876	P83877
RefSeq (mRNA)	NM_001303471	NM_001038608
RefSeq (protein)	NP_001290400	NP_001033697
Location (UCSC)	Chr 18: 79.97 – 80.03 Mb	Chr 18: 80.21 – 80.22 Mb
PubMed search

Thioredoxin-like protein 4A is a protein that in humans is encoded by the TXNL4A gene.^[1][2]

Interactions

TXNL4A has been shown to interact with PQBP1.^[3]

References

1. Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics 1 (3): 109–18. PMID 11015569.
2. "Entrez Gene: TXNL4A thioredoxin-like 4A".
3. Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

Further reading

• Reuter K, Nottrott S, Fabrizio P, Lührmann R, Ficner R (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.". J. Mol. Biol. 294 (2): 515–25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
• Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1.". Gene 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
• Zhang YZ, Cheng H, Gould KL, Golemis EA, Roder H (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis.". Biochemistry 42 (32): 9609–18. doi:10.1021/bi034486i. PMID 12911302.
• Laggerbauer B, Liu S, Makarov E, Vornlocher HP, Makarova O, Ingelfinger D, Achsel T, Lührmann R (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity.". Chemical biology & drug design 68 (5): 266–72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886.