Task-negative

In neuroscience, a Task-negative (TN) mode, also known as the default mode network, is inversely correlated to the Task-positive mode.[1] Its main function is to reorient attention towards salient stimuli. TN is considered to be involved mostly, if not entirely, in involuntary actions. The neural network is right hemisphere lateralized and includes the right temporal-parietal junction and the right ventral frontal cortex.[2] This system shows activity increases upon detection of salient targets, especially when they appear in unexpected locations.[3][4][5][6][7] Activity increases also are observed in the ventral system after abrupt changes in sensory stimuli,[8] at the onset and offset of task blocks,[9] and at the end of a completed trial.[10]

Role in disease

Studies have reported a hyper-connectivity of TN brain regions in depression during rest.[11][12]

See also

References

  1. ↑ Spreng, R. Nathan. "The Fallacy of a "Task-Negative" Network". Frontiers in Psychology 3. doi:10.3389/fpsyg.2012.00145.
  2. ↑ Fox, M.D., Corbetta, M., Snyder, A.Z., Vincent, J.L., & Raichle, M.E. (2006). Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. PNAS, 103, 10046-10051.
  3. ↑ Posner, M. I. & Petersen, S. E. (1990). Annual Review of Neuroscience, 13, 25–42.
  4. ↑ Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P. & Shulman, G. L. (2000). Nature Neuroscience, 3, 292–297.
  5. ↑ Astafiev, S. V., Shulman, G. I., Stanley, C. M., Snyder, A. Z., Van Essen, D. C. & Corbetta, M. (2003). Journal of Neuroscience, 23, 4689–4699.
  6. ↑ Ast afiev, S. V., St anley, C. M., Shulman, G. L. & Corbetta, M. (2004) Nature Neuroscience, 7, 542–548.
  7. ↑ Kincade, J. M., Abrams, R. A., Astafiev, S. V., Shulman, G. I. & Corbetta, M. (2005). Journal of Neuroscience, 25, 4593– 4604.
  8. ↑ Downar, J., Crawley, A. P., Mikulis, D. J. & Dav is, K. D. (2000) Nature Neuroscience, 3, 277–283.
  9. ↑ Fox, M. D., Snyder, A. Z., Barch, D. M., Gusnard, D. A. & Raichle, M. E. (2005). NeuroImage, 28, 956–966.
  10. ↑ Shulman, G. I., Tansy, A. P., Kincade, M., Petersen, S. E., McAvoy, M. P. & Corbetta, M. (2002). Cerebral Cortex, 12, 590–600.
  11. ↑ Zhou, Yuan; Yu, Chunshui; Zheng, Hua; Liu, Yong; Song, Ming; Qin, Wen; Li, Kuncheng; Jiang, Tianzi (2010). "Increased neural resources recruitment in the intrinsic organization in major depression". Journal of Affective Disorders 121 (3): 220–230. doi:10.1016/j.jad.2009.05.029. PMID 19541369.
  12. ↑ Berman, M. G.; Peltier, S.; Nee, D. E.; Kross, E.; Deldin, P. J.; Jonides, J. (19 September 2010). "Depression, rumination and the default network". Social Cognitive and Affective Neuroscience 6 (5): 548–555. doi:10.1093/scan/nsq080. PMID 20855296.
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