Telomestatin
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| Identifiers | |
|---|---|
265114-54-3  | |
| ChEMBL | ChEMBL443683  |
| Jmol interactive 3D | Image |
| PubChem | 11954679 |
| |
| Properties | |
| C26H14N8O7S | |
| Molar mass | 582.51 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells.[1] It was first isolated from the bacteria Streptomyces anulatus.[1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
References
- 1 2 Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo (2001). "Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus". Journal of the American Chemical Society 123 (6): 1262–1263. doi:10.1021/ja005780q. PMID 11456694.
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