Terodiline

Terodiline
Systematic (IUPAC) name

N-tert-butyl-4,4-di(phenyl)butan-2-amine
Identifiers
ATC code	G04BD05 (WHO)
PubChem	CID 23480
ChemSpider	21952^Y
UNII	70KG06964W^Y
ChEMBL	CHEMBL363295^Y
Chemical data
Formula	C₂₀H₂₇N
Molar mass	281.435 g/mol
SMILES c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
InChI InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3^Y Key:UISARWKNNNHPGI-UHFFFAOYSA-N^Y
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Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.^[1]

References

↑ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA. "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence".

Urologicals, including antispasmodics (G04B)

Acidifiers	Ammonium chloride Calcium chloride

Urinary antispasmodics (primarily antimuscarinics)	Darifenacin Emepronium Fesoterodine Flavoxate Imidafenacin Meladrazine Mirabegron Oxybutynin Propiverine Solifenacin Terodiline Tolterodine Trospium chloride

Other urologicals	Urea analogues: Acetohydroxamic acid Salicylhydroxamic acid Other: Collagen Dimethyl sulfoxide Magnesium hydroxide Pentosan polysulfate Phenazopyridine Phenyl salicylate Succinimide

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