Tetrahydrocannabinolic acid synthase

Tetrahydrocannabinolic acid synthase (EC 1.21.3.7, THCA synthase, Delta1-tetrahydrocannabinolic acid synthase) is an enzyme with systematic name cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming).^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

cannabigerolate + O₂

\rightleftharpoons

Delta9-tetrahydrocannabinolate + H₂O₂

Tetrahydrocannabinolic acid synthase is a flavoprotein (FAD).

References

↑ Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. (1995). "First direct evidence for the mechanism of Δ¹-tetrahydrocannabinolic acid biosynthesis". J. Am. Chem. Soc. 117: 9766–9767. doi:10.1021/ja00143a024.
↑ Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. (2004). "The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ¹-tetrahydrocannabinolic acid synthase from Cannabis sativa L". J. Biol. Chem. 279 (38): 39767–39774. doi:10.1074/jbc.M403693200. PMID 15190053.
↑ Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. (2005). "Crystallization of Δ¹-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 8): 799–801. doi:10.1107/S1744309105023365. PMID 16511162.
↑ Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. (2012). "Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". J. Mol. Biol. 423 (1): –. doi:10.1016/j.jmb.2012.06.030. PMID 22766313.

External links

Tetrahydrocannabinolic acid synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Other oxidoreductases (EC 1.15-1.21)

1.15: Acting on superoxide as acceptor	Superoxide dismutase SOD1 SOD2 SOD3

1.16: Oxidizing metal ions	Ceruloplasmin

1.17: Acting on CH or CH2 groups	Xanthine oxidase Ribonucleotide reductase 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase

1.18: Acting on iron-sulfur proteins as donors	Nitrogenase

1.19: Acting on reduced flavodoxin as donor	Nitrogenase (flavodoxin)

1.20: Acting on phosphorus or arsenic in donors	Glutaredoxin GLRX GLRX2 GLRX3 GLRX5

1.21: Acting on X-H and Y-H to form an X-Y bond	Isopenicillin N synthase Columbamine oxidase Reticuline oxidase Sulochrin oxidase (+)-bisdechlorogeodin-forming (-)-bisdechlorogeodin-forming Aureusidin synthase Tetrahydrocannabinolic acid synthase Cannabidiolic acid synthase Dichlorochromopyrrolate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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