CLEC3B

C-type lectin domain family 3, member B
PDB rendering based on 1htn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1HTN​, 1RJH​, 1TN3​, 3L9J​
Identifiers
Symbols	CLEC3B ; TN; TNA
External IDs	OMIM: 187520 MGI: 104540 HomoloGene: 31145 GeneCards: CLEC3B Gene
Gene ontology Molecular function • calcium ion binding • heparin binding • carbohydrate binding • kringle domain binding Cellular component • granular component • extracellular region • extracellular space • cytoplasm • extracellular matrix • extracellular exosome Biological process • skeletal system development • ossification • positive regulation of plasminogen activation • bone mineralization • cellular response to organic substance • cellular response to transforming growth factor beta stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7123	21922
Ensembl	ENSG00000163815	ENSMUSG00000025784
UniProt	P05452	Q8CFZ6
RefSeq (mRNA)	NM_001308394	NM_011606
RefSeq (protein)	NP_001295323	NP_035736
Location (UCSC)	Chr 3: 45 – 45.04 Mb	Chr 9: 123.15 – 123.16 Mb
PubMed search

Tetranectin is a protein that in humans is encoded by the CLEC3B gene.^[1]

References

1. "Entrez Gene: CLEC3B C-type lectin domain family 3, member B".

Further reading

• Wewer UM, Albrechtsen R (1992). "Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer.". Lab. Invest. 67 (2): 253–62. PMID 1354271.
• Berglund L, Petersen TE (1992). "The gene structure of tetranectin, a plasminogen binding protein.". FEBS Lett. 309 (1): 15–9. doi:10.1016/0014-5793(92)80729-Z. PMID 1511740.
• Borregaard N, Christensen L, Bejerrum OW; et al. (1990). "Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase.". J. Clin. Invest. 85 (2): 408–16. doi:10.1172/JCI114453. PMC 296439. PMID 2298916.
• Clemmensen I (1990). "Interaction of tetranectin with sulphated polysaccharides and trypan blue.". Scand. J. Clin. Lab. Invest. 49 (8): 719–25. doi:10.3109/00365518909091550. PMID 2533389.
• Clemmensen I, Petersen LC, Kluft C (1986). "Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma: tetranectin.". Eur. J. Biochem. 156 (2): 327–33. doi:10.1111/j.1432-1033.1986.tb09586.x. PMID 3009181.
• Fuhlendorff J, Clemmensen I, Magnusson S (1988). "Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein.". Biochemistry 26 (21): 6757–64. doi:10.1021/bi00395a027. PMID 3427041.
• Wewer UM, Ibaraki K, Schjørring P; et al. (1995). "A potential role for tetranectin in mineralization during osteogenesis.". J. Cell Biol. 127 (6 Pt 1): 1767–75. doi:10.1083/jcb.127.6.1767. PMC 2120295. PMID 7798325.
• Nielsen H, Clemmensen I, Kharazmi A (1993). "Tetranectin: a novel secretory protein from human monocytes.". Scand. J. Immunol. 37 (1): 39–42. doi:10.1111/j.1365-3083.1993.tb01662.x. PMID 8418471.
• Durkin ME, Naylor SL, Albrechtsen R, Wewer UM (1997). "Assignment of the gene for human tetranectin (TNA) to chromosome 3p22→p21.3 by somatic cell hybrid mapping.". Cytogenet. Cell Genet. 76 (1-2): 39–40. doi:10.1159/000134509. PMID 9154122.
• Nielsen BB, Kastrup JS, Rasmussen H; et al. (1997). "Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.". FEBS Lett. 412 (2): 388–96. doi:10.1016/S0014-5793(97)00664-9. PMID 9256258.
• Kastrup JS, Nielsen BB, Rasmussen H; et al. (1998). "Structure of the C-type lectin carbohydrate recognition domain of human tetranectin.". Acta Crystallogr. D Biol. Crystallogr. 54 (Pt 5): 757–66. doi:10.1107/S0907444997016806. PMID 9757090.
• Jaquinod M, Holtet TL, Etzerodt M; et al. (2000). "Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin.". Biol. Chem. 380 (11): 1307–14. doi:10.1515/BC.1999.166. PMID 10614823.
• Lorentsen RH, Graversen JH, Caterer NR; et al. (2000). "The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.". Biochem. J. 347 Pt 1 (1): 83–7. doi:10.1042/0264-6021:3470083. PMC 1220934. PMID 10727405.
• Graversen JH, Jacobsen C, Sigurskjold BW; et al. (2001). "Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold.". J. Biol. Chem. 275 (48): 37390–6. doi:10.1074/jbc.M004873200. PMID 10964919.
• Arvanitis DL, Kamper EF, Kopeikina L; et al. (2002). "Tetranectin expression in gastric adenocarcinomas.". Histol. Histopathol. 17 (2): 471–5. PMID 11962752.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Westergaard UB, Andersen MH, Heegaard CW; et al. (2003). "Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator.". Eur. J. Biochem. 270 (8): 1850–4. doi:10.1046/j.1432-1033.2003.03549.x. PMID 12694198.
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hermann M, Pirkebner D, Draxl A; et al. (2005). "In the search of potential human islet stem cells: is tetranectin showing us the way?". Transplant. Proc. 37 (2): 1322–5. doi:10.1016/j.transproceed.2004.12.050. PMID 15848710.