Theta-burst stimulation

Theta-burst stimulation (TBS) is a protocol used in transcranial magnetic stimulation. It was originally described by Huang in 2005 [1] The protocol has been used in Major Depressive Disorder with stimulation of both right and left Dorsolateral Prefrontal Cortex (DLPFC). The left is stimulated (TBS) while the right is inhibited (cTBS). In the theta-burst stimulation pattern, 3 pulses are administered at 50 Hz, every 200 ms. In the intermittent theta burst stimulation pattern (iTBS), a 2 second train of TBS is repeated every 10 s for a total of 190 s (600 pulses). In the continuous theta burst stimulation paradigm (cTBS), a 40 s train of uninterrupted TBS is given (600 pulses).

In a March 2015 publication Bakker .[2] demonstrated with 185 patients evenly divided between the standard 10 hz protocol (30 min) and the theta-burst stimulation, that the outcome (reduction of Ham-D and BDI scores) was the same. Although widely used in functional brain research, it has not yet been adopted in clinical care nor approved by the FDA.

Theta Burst Stimulation of the Human Motor Cortex

References

  1. ↑ Huang et al: "Theta Burst Stimulation of the Human Motor Cortex" 2005
  2. ↑ Bakker et al: rTMS of the Dorsomedial Prefrontal Cortex for Major Depression: Safety, Tolerability, Effectiveness, and Outcome Predictors for 10 Hz Versus Intermittent Theta-burst Stimulation 2003
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