Thunberginol A

Thunberginol A

Names
IUPAC name 3-(3,4-dihydroxyphenyl)-8-hydroxyisochromen-1-one
Identifiers
CAS Number	147666-80-6
Jmol interactive 3D	Image
PubChem	5321948
SMILES C1=CC2=C(C(=C1)O)C(=O)OC(=C2)C3=CC(=C(C=C3)O)O
Properties
Chemical formula	C15H10O5
Molar mass	270.23 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Thunberginol A is an isocoumarin found in Hydrangea macrophylla^[1] and in its processed leaves form (Hydrangeae dulcis folium).^[2][3]

References

1. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols a and F from Hydrangea macrophylla SERINGE var. Thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin 22 (8): 870–872. doi:10.1248/bpb.22.870. PMID 10480329. INIST:1959604.
2. Yamahara, J.; Matsuda, H.; Shimoda, H.; Wariishi, N.; Yagi, N.; Murakami, N.; Yoshikawa, M. (1995). "Effects of thunberginol a contained in Hydrangeae dulcis forium on types I-IV allergies". Nihon yakurigaku zasshi. Folia pharmacologica Japonica (in Japanese) 105 (5): 365–379. PMID 7628785.
3. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1998). "Immunomodulatory activity of thunberginol a and related compounds isolated from hydrangeae dulcis folium on splenocyte proliferation activated by mitogens". Bioorganic & Medicinal Chemistry Letters 8 (3): 215. doi:10.1016/S0960-894X(97)10221-9.