Tilorone

Tilorone

Systematic (IUPAC) name
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Identifiers
CAS Number	27591-97-5
ATC code	none
PubChem	CID 5475
ChemSpider	5276
UNII	O6W7VEW6KS
ChEMBL	CHEMBL47298
Chemical data
Formula	C25H34N2O3
Molar mass	410.55 g/mol
SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 Key:MPMFCABZENCRHV-UHFFFAOYSA-N
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Tilorone (trade name Amixin IC) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[1] It is used as an antiviral drug.

Pharmacology

Tilorone activates the production of interferon.^[1]

According to the results of clinical tests, conducted in Kyiv, the efficacy of prophylactic action of tilorone was 93.7%.

Uses

Tilorone is used for different viral diseases: influenza, hepatitis, herpes, diarrhea and others. In addition, it is used in the treatment of multiple sclerosis, urinary tract infections and other viral and autoimmune diseases.

References

1. Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother 2 (2): 73–8. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.