TOMM20

Translocase of outer mitochondrial membrane 20 homolog (yeast)
PDB rendering based on 1om2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4APO​
Identifiers
Symbols	TOMM20 ; MAS20; MOM19; TOM20
External IDs	OMIM: 601848 MGI: 1915202 HomoloGene: 44649 GeneCards: TOMM20 Gene
Gene ontology Molecular function • protein binding • P-P-bond-hydrolysis-driven protein transmembrane transporter activity • unfolded protein binding Cellular component • mitochondrion • mitochondrial outer membrane • mitochondrial outer membrane translocase complex • integral component of membrane • ER-mitochondrion membrane contact site Biological process • protein targeting to mitochondrion • cellular protein metabolic process • protein transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9804	67952
Ensembl	ENSG00000173726	ENSMUSG00000093904
UniProt	Q15388	Q9DCC8
RefSeq (mRNA)	NM_014765	NM_024214
RefSeq (protein)	NP_055580	NP_077176
Location (UCSC)	Chr 1: 235.11 – 235.13 Mb	Chr 8: 126.93 – 126.95 Mb
PubMed search

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.^[1][2][3][4]

References

1. Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, Schafer E, Nomura N, Pfanner N (Jan 1996). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Lett 375 (3): 307–10. doi:10.1016/0014-5793(95)01229-8. PMID 7498524.
2. Goping IS, Millar DG, Shore GC (Nov 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Lett 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID 7589431.
3. Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR, Lithgow T (Feb 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". J Mol Biol 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID 15733919.
4. "Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Schleiff E, Shore GC, Goping IS (1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins". FEBS Lett. 404 (2–3): 314–8. doi:10.1016/S0014-5793(97)00145-2. PMID 9119086.
• Schleiff E, Shore GC, Goping IS (1997). "Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements". J. Biol. Chem. 272 (28): 17784–9. doi:10.1074/jbc.272.28.17784. PMID 9211931.
• Schleiff E, Turnbull JL (1998). "Characterization of the N-terminal targeting signal binding domain of the mitochondrial outer membrane receptor, Tom20". Biochemistry 37 (38): 13052–8. doi:10.1021/bi980746y. PMID 9748310.
• Yano M, Kanazawa M, Terada K, et al. (1998). "Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria". J. Biol. Chem. 273 (41): 26844–51. doi:10.1074/jbc.273.41.26844. PMID 9756929.
• Hernández JM, Giner P, Hernández-Yago J (1999). "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes". Gene 239 (2): 283–91. doi:10.1016/S0378-1119(99)00409-6. PMID 10548729.
• Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
• Yano M, Hoogenraad N, Terada K, Mori M (2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol. Cell. Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
• Abdul KM, Terada K, Yano M, et al. (2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex". Biochem. Biophys. Res. Commun. 276 (3): 1028–34. doi:10.1006/bbrc.2000.3589. PMID 11027586.
• Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
• Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

See Also

• Mitochondria Outer Membrane Translocase
• TOMM22
• TOMM40
• TOMM70A