Tomas Lindahl

Tomas Lindahl

Tomas Lindahl at the Royal Swedish Academy of Sciences (2015)
Born Tomas Robert Lindahl
(1938-01-28) 28 January 1938[1]
Stockholm, Sweden
Nationality Swedish, naturalised British
(dual nationality)
Fields
Institutions
Alma mater
Thesis On the structure and stability of nucleic acids in solution (1967)
Known for Clarification of cellular resistance to carcinogens
Influences Walter Bodmer
Notable awards
Website
crick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/

Tomas Robert Lindahl FRS[3] FMedSci[4] (born 28 January 1938) is a Swedish-born British scientist specialising in cancer research.[5]

In 2015, he was awarded the Nobel Prize in Chemistry[6] jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.[7][8][9]

Education

Lindahl was born in Kungsholmen, Stockholm, Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg.[10] He received a PhD degree in 1967,[11] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.[1]

Career

After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University and Rockefeller University.[12] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.[12] From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[13] He continued to research there until 2009.

He has contributed to many papers on DNA repair and the genetics of cancer.[14][15][16][17][18][19][20][21][22]

Awards and honours

Lindahl received the Royal Society's Royal Medal in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[23] He is a member of the Norwegian Academy of Science and Letters.[24] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. He was elected a Fellow of the Royal Society (FRS) in 1988,[25] his certificate of election reads:

“ Dr. Tomas Lindahl is noted for his contributions to the comprehension of DNA repair at the molecular level in bacterial and mammalian cells. He was the first to isolate a mammalian DNA ligase and to describe a totally unanticipated novel group of DNA glycosylases as mediators of DNA excision repair. He has also discovered a unique class of enzymes in mammalian cells, namely the methyltransferases, which mediate the adaptive response to alkylation of DNA and has shown that the expression of these enzymes is regulated by the ada gene. More recently he has elucidated the molecular defect in Blooms syndrome [sic] to be the lack of DNA ligase I. Apart from providing profound insights into the nature of the DNA repair process his very important contributions promise to facilitate the design of more selective chemotherapeutic drugs for the treatment of cancer. Lindahl has also made a number of significant contributions to understanding at the DNA level the mechanism of transformation of B-lymphocytes by the Epstein-Barr virus. The most notable of these was the first description of the occurrence in lymphoid cells of closed circular duplex viral DNA.[3] ”

He shared the Nobel Prize in Chemistry in 2015.[7] The Swedish Academy noted that "The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[26]

References

  1. 1 2 LINDAHL,. Who's Who 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. ↑ Lindahl, Tomas (2013). "My Journey to DNA Repair". Genomics, Proteomics & Bioinformatics 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229.
  3. 1 2 3 "Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. Archived from the original on 2014-11-21.
  4. 1 2 "Dr Tomas Lindahl FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 2015-10-08.
  5. ↑ "Emeritus Scientist - Tomas Lindahl". The Crick. Archived from the original on 2015-12-01.
  6. ↑ Tomas Lindahl - Nobel Prize in Chemistry 2015 on Vimeo
  7. 1 2 Broad, William J. (2015-10-07). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved 2015-10-07.
  8. ↑ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved 7 October 2015.
  9. ↑ Cressey, Daniel (2015). "DNA repair sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar share 2015 prize". Nature 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021.
  10. ↑ Sweden, Indexed Birth Records, 1860–1941
  11. ↑ Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution. Stockholm.
  12. 1 2 "Cancer Research UK Grants & Research – Tomas Lindahl". Retrieved 2008-11-10.
  13. ↑ "4 ways that Tomas Lindahl’s Nobel Prize for Chemistry revolutionised cancer research", by Emma Smith, CRUK Science blog, October 7, 2015
  14. ↑ Gerken, T. is; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  15. ↑ Tomas Lindahl's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  16. ↑ Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature 362 (6422): 709–15. doi:10.1038/362709a0. PMID 8469282.
  17. ↑ Wood, R. D. (2001). "Human DNA Repair Genes". Science 291 (5507): 1284–9. doi:10.1126/science.1056154. PMID 11181991.
  18. ↑ Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature 356 (6367): 356. doi:10.1038/356356a0. PMID 1549180.
  19. ↑ Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature 419 (6903): 174–8. doi:10.1038/nature00908. PMID 12226667.
  20. ↑ Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983.
  21. ↑ Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533.
  22. ↑ Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, F. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Lynch, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, J. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, D. E.; Lindahl, T (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398.
  23. ↑ "Royal recent winners". Retrieved 2008-11-10.
  24. ↑ "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Science and Letters. Retrieved 7 October 2010.
  25. ↑ "Dr Tomas Lindahl FMedSci FRS". London: Royal Society. Archived from the original on 2015-09-22.
  26. ↑ "The Nobel Prize in Chemistry 2015". nobelprize.org.
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