Topogenic sequence

A topogenic sequence is a peptide sequence present at the N-terminus of nascent proteins. The sequence is composed of at least two parts: a signal peptide and a transit peptide. It acts to translocate proteins across various intracellular membranes,[1] and ensure they are transported to the correct organelle after synthesis.[2] The sequence is then proteolytically removed after import.

As an example, the vast majority of all known complex plastid preproteins (an 'unactivated' protein) encoded in the nucleus possess a topogenic sequence.[2]

See also

References

  1. ↑ Robinson, A; Austen, B (1 September 1987). "The role of topogenic sequences in the movement of proteins through membranes.". Biochem J. 246 (2): 249–261.
  2. 1 2 Gould, Sven; Waller, R; McFadden, G (June 2008). "Plastid Evolution". Annual Review of Plant Biology 59: 491–517. doi:10.1146/annurev.arplant.59.032607.092915. PMID 18315522.


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