Torulene dioxygenase

Torulene dioxygenase (EC 1.13.11.59, CAO-2, CarT) is an enzyme with systematic name torulene:oxygen oxidoreductase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

torulene + O₂

\rightleftharpoons

4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal

It is assumed that 3-methylbut-2-enal is formed.

References

↑ Prado-Cabrero, A., Estrada, A.F., Al-Babili, S. and Avalos, J. (2007). "Identification and biochemical characterization of a novel carotenoid oxygenase: elucidation of the cleavage step in the Fusarium carotenoid pathway". Mol. Microbiol. 64 (2): 448–460. doi:10.1111/j.1365-2958.2007.05665.x. PMID 17493127.
↑ Saelices, L., Youssar, L., Holdermann, I., Al-Babili, S. and Avalos, J. (2007). "Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway". Mol. Genet. Genomics 278 (5): 527–537. doi:10.1007/s00438-007-0269-2. PMID 17610084.
↑ Estrada, A.F., Maier, D., Scherzinger, D., Avalos, J. and Al-Babili, S. (2008). "Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation". Fungal Genet. Biol. 45 (11): 1497–1505. doi:10.1016/j.fgb.2008.09.001. PMID 18812228.

External links

Torulene dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: monooxygenases (EC 1.13)

1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase

1.13.12: one atom of oxygen	Firefly luciferase

1.13.99: other	Inositol oxygenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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