Translation initiation factor IF-3

Translation initiation factor IF-3, N-terminal domain

translation initiation factor 3 n-terminal domain
Identifiers
Symbol IF3_N
Pfam PF05198
InterPro IPR019814
PROSITE PDOC00723
SCOP 1tif
SUPERFAMILY 1tif
Translation initiation factor IF-3, C-terminal domain

translation initiation factor 3 c-terminal domain
Identifiers
Symbol IF3_C
Pfam PF00707
InterPro IPR019815
PROSITE PDOC00723
SCOP 1tif
SUPERFAMILY 1tif

In molecular biology, translation initiation factor IF-3 (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consists of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit.[1] The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3.[2]


References

  1. Liveris D, Schwartz JJ, Geertman R, Schwartz I (September 1993). "Molecular cloning and sequencing of infC, the gene encoding translation initiation factor IF3, from four enterobacterial species". FEMS Microbiol. Lett. 112 (2): 211–6. doi:10.1111/j.1574-6968.1993.tb06450.x. PMID 8405963.
  2. Lin Q, Ma L, Burkhart W, Spremulli LL (April 1994). "Isolation and characterization of cDNA clones for chloroplast translational initiation factor-3 from Euglena gracilis". J. Biol. Chem. 269 (13): 9436–44. PMID 8144528.

This article incorporates text from the public domain Pfam and InterPro IPR019815

This article incorporates text from the public domain Pfam and InterPro IPR019814

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