Trichodysplasia spinulosa polyomavirus

Trichodysplasia spinulosa-associated polyomavirus
Virus classification
Group: Group I (dsDNA)
Family: Polyomaviridae
Genus: Orthopolyomavirus
Species: Trichodysplasia spinulosa-associated polyomavirus

Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a type of human polyomavirus. It is associated with trichodysplasia spinulosa, a rare skin disease only seen in immunocompromised patients. The virus was first described in July 2010.[1] Trichodysplasia spinulosa[2] is a proliferative[3] skin disorder and had been long suspected to be associated with viral infection, particularly a polyomavirus infection, by electron microscopic studies.[4] The Feltkamp laboratory at Leiden University Medical Center, the Netherlands, isolated this virus' DNA using rolling circle amplification. TSPyV is actually an extremely common component of human viral skin flora.[5] Unlike Merkel cell carcinoma caused mostly by Merkel cell polyomavirus, trichodysplasia spinulosa is a dysplasia[6] rather than a neoplasia and TSPyV appears to be actively replicating in the hair follicle inner root sheath cells. Thus, antiviral therapies currently available may have benefit in this disorder. TSPyV is the eighth human polyomavirus to be discovered.

References

  1. ↑ Van der Meijden, E; Janssens, RWA; Lauber, C; Bouwes Bavinck, JN; Gorbalenya, AE; et al. (2010). "Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient". PLoS Pathog 6 (7): e1001024. doi:10.1371/journal.ppat.1001024. PMC: 2912394. PMID 20686659.
  2. ↑ "The trichodysplasia spinulosa-associated polyomavirus: virological background and clinical implications". APMIS 121 (8): 770–82. Aug 2013. doi:10.1111/apm.12092.
  3. ↑ "Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21". PLOS ONE 9 (10): e108947. Oct 2014. doi:10.1371/journal.pone.0108947. PMC: 4188587. PMID 25291363.
  4. ↑ "Trichodysplasia of immunosuppression treated with oral valganciclovir.". J Am Acad Dermatol 60: 169–72. Jan 2009. doi:10.1016/j.jaad.2008.07.051. PMC: 2708076. PMID 19103376.
  5. ↑ http://wwwnc.cdc.gov/eid/article/17/8/11-0114_article.htm
  6. ↑ "Trichodysplasia spinulosa is characterized by active polyomavirus infection". J Clin Virol 53 (3): 225–30. Mar 2012. doi:10.1016/j.jcv.2011.11.007. PMID 22196870.

External links

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