Trimethylamine-N-oxide reductase

trimethylamine-N-oxide reductase
Identifiers
EC number	1.6.6.9
CAS number	37256-34-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a trimethylamine-N-oxide reductase (EC 1.6.6.9) is an enzyme that catalyzes the chemical reaction

NADH + H⁺ + trimethylamine N-oxide $\rightleftharpoons$ NAD⁺ + trimethylamine + H₂O

The 3 substrates of this enzyme are NADH, H⁺, and trimethylamine N-oxide, whereas its 3 products are NAD⁺, trimethylamine, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a nitrogenous group as acceptor. The systematic name of this enzyme class is NADH:trimethylamine-N-oxide oxidoreductase. Other names in common use include trimethylamine N-oxide reductase, trimethylamine oxide reductase, TMAO reductase, and TOR. This enzyme participates in methane metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TMO.

References

• Unemoto T, Hayashi M, Miyaki K, Hayashi M (1965). "Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus". Biochim. Biophys. Acta 110 (2): 319–28. doi:10.1016/s0926-6593(65)80039-x. PMID 4286289.