Trofile assay

The Trofile assay is a blood test that identifies the tropism of a patient's HIV.

A molecular assay, Trofile was developed by Monogram Biosciences for use in HIV treatment. The assay's purpose is to identify the tropism of an individual patient's HIV strain – R5, X4, or a combination of these known as dual/mixed (D/M). The results show whether the patient is infected with virus that enters cells using the R5 co-receptor, the X4 co-receptor, or both (dual/mixed).

Patients with strains of HIV that prefer the R5 receptor tend to remain healthy longer than those with the strains that prefer X4. However, over the course of the disease, a patient's viral population may undergo a "tropism switch" from R5 to X4.

References

External links


This article is issued from Wikipedia - version of the Sunday, October 19, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.